Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq
Introduction: Toxoplasma gondii is an opportunistic protozoan parasite that causes a life-threatening disease – toxoplasmosis – in immunocompromised individuals, including patients with cancer. This prospective cross-sectional study set out to determine the prevalence of toxoplasmosis in patients w...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-11-01
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| Series: | Iranian Journal of Parasitology |
| Subjects: | |
| Online Access: | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3929 |
| _version_ | 1827587780806443008 |
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| author | Latif O Mohammed Ahmed MS Amin Rezan M Mohammed Shad A Mohammed Lava I Ahmed Vania R Ahmed Shaz BD Majid Bryar O Mohammed |
| author_facet | Latif O Mohammed Ahmed MS Amin Rezan M Mohammed Shad A Mohammed Lava I Ahmed Vania R Ahmed Shaz BD Majid Bryar O Mohammed |
| author_sort | Latif O Mohammed |
| collection | DOAJ |
| description |
Introduction: Toxoplasma gondii is an opportunistic protozoan parasite that causes a life-threatening disease – toxoplasmosis – in immunocompromised individuals, including patients with cancer. This prospective cross-sectional study set out to determine the prevalence of toxoplasmosis in patients with cancer compared with that of healthy individuals.
Materials & Methods: Anti-T.gondii IgG and IgM antibodies were measured in the blood samples of 113 patients with cancer (80 with solid organ tumours and 33 with haematological malignancies) and 82 healthy controls, using chemiluminescence microparticle immunoassay (CMIA).
Results: The prevalence of anti-T.gondii IgG was 39.8% in the patient group and 24.4% in the control group, which amounted to a significant difference (p = 0.024). Only one case of anti-T.gondii IgM positivity was observed in the patient group, and no IgM seropositivity was reported in the control group. Moreover, the seroprevalence of anti-T.gondii IgG was non-significantly higher (p = 0.102) in the patients with haematological malignancies (51.5%) than in those with solid organ tumours (35%).
Conclusion: These results demonstrate that the prevalence of T. gondii infection is higher in patients with cancer than in healthy individuals. Therefore, T. gondii screening in patients with cancer is recommended.
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| first_indexed | 2024-03-09T00:22:57Z |
| format | Article |
| id | doaj.art-0cdcda8fac6249629ce81f5e9ba1b4ba |
| institution | Directory Open Access Journal |
| issn | 1735-7020 2008-238X |
| language | English |
| last_indexed | 2024-03-09T00:22:57Z |
| publishDate | 2023-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Parasitology |
| spelling | doaj.art-0cdcda8fac6249629ce81f5e9ba1b4ba2023-12-12T04:54:26ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2023-11-0118410.18502/ijpa.v18i4.14261Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, IraqLatif O Mohammed0Ahmed MS Amin1Rezan M Mohammed2Shad A Mohammed3Lava I Ahmed4Vania R Ahmed5Shaz BD Majid6Bryar O Mohammed7Department of Microbiology, College of Medicine, University of Sulaimani, Sulaimani, IraqDepartment of Biology, College of Science, University of Sulaimani, Sulaimani, IraqDepartment of Biology, College of Science, University of Sulaimani, Sulaimani, IraqDepartment of Biology, College of Science, University of Sulaimani, Sulaimani, IraqDepartment of Biology, College of Science, University of Sulaimani, Sulaimani, IraqWise Private Preparatory School for Girls, Sulaimani, IraqAshty Private Elementary School, Sulaimani, IraqHiwa Cancer Hospital, Sulaimani, Iraq Introduction: Toxoplasma gondii is an opportunistic protozoan parasite that causes a life-threatening disease – toxoplasmosis – in immunocompromised individuals, including patients with cancer. This prospective cross-sectional study set out to determine the prevalence of toxoplasmosis in patients with cancer compared with that of healthy individuals. Materials & Methods: Anti-T.gondii IgG and IgM antibodies were measured in the blood samples of 113 patients with cancer (80 with solid organ tumours and 33 with haematological malignancies) and 82 healthy controls, using chemiluminescence microparticle immunoassay (CMIA). Results: The prevalence of anti-T.gondii IgG was 39.8% in the patient group and 24.4% in the control group, which amounted to a significant difference (p = 0.024). Only one case of anti-T.gondii IgM positivity was observed in the patient group, and no IgM seropositivity was reported in the control group. Moreover, the seroprevalence of anti-T.gondii IgG was non-significantly higher (p = 0.102) in the patients with haematological malignancies (51.5%) than in those with solid organ tumours (35%). Conclusion: These results demonstrate that the prevalence of T. gondii infection is higher in patients with cancer than in healthy individuals. Therefore, T. gondii screening in patients with cancer is recommended. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3929Toxoplasma gondiiSeroprevalenceCancerOpportunistic infectionImmunocompromised patients |
| spellingShingle | Latif O Mohammed Ahmed MS Amin Rezan M Mohammed Shad A Mohammed Lava I Ahmed Vania R Ahmed Shaz BD Majid Bryar O Mohammed Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq Iranian Journal of Parasitology Toxoplasma gondii Seroprevalence Cancer Opportunistic infection Immunocompromised patients |
| title | Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq |
| title_full | Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq |
| title_fullStr | Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq |
| title_full_unstemmed | Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq |
| title_short | Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq |
| title_sort | seroprevalence of anti toxoplasma gondii antibodies among patients with cancer at hiwa cancer hospital in sulaimani city kurdistan region iraq |
| topic | Toxoplasma gondii Seroprevalence Cancer Opportunistic infection Immunocompromised patients |
| url | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3929 |
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