Protein and peptide profiles of rats’ organs in scorpion envenomation
Problem of scorpion envenomation becomes more alarming each year. Main effects of scorpion venom are commonly believed to be related to its neurotoxic properties, yet severe symptoms may also be developed due to the uncontrolled enzymatic activity and formation of various bioactive molecules, includ...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023000604 |
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| author | Valery Gunas Oleksandr Maievskyi Nataliia Raksha Tetiana Vovk Oleksiy Savchuk Serhii Shchypanskyi Igor Gunas |
| author_facet | Valery Gunas Oleksandr Maievskyi Nataliia Raksha Tetiana Vovk Oleksiy Savchuk Serhii Shchypanskyi Igor Gunas |
| author_sort | Valery Gunas |
| collection | DOAJ |
| description | Problem of scorpion envenomation becomes more alarming each year. Main effects of scorpion venom are commonly believed to be related to its neurotoxic properties, yet severe symptoms may also be developed due to the uncontrolled enzymatic activity and formation of various bioactive molecules, including middle-mass molecules (MMMs). MMMs are considered as endogenous intoxication markers, their presence may indicate multiple organ failure. Scorpions, belong to the Leiurus macroctenus species, are very dangerous, nevertheless, effects of their venom on protein and peptide composition within the tissues remains unclear. In this work we have focused the attention on changes in protein and MMM levels and peptide composition in various organs during Leiurus macroctenus envenomation. The results revealed a decrease in protein level during envenomation as well as a significant increment of MMM210 and MMM254 levels in all assessed organs. Quantitative and qualitative compositions of various protein and peptide factions were continually changing. All of this may suggest that Leiurus macroctenus sting causes considerable destruction of cell microenvironment across all essential organs, providing systemic envenomation. In addition, MMM level increment may indicate endogenous intoxication development. Peptides, formed during envenomation, may possess various bioactive properties, analysis of which constitutes an area of further studies. |
| first_indexed | 2024-03-13T04:10:04Z |
| format | Article |
| id | doaj.art-0cdd68ab4271485bb2da0d1041a02cd6 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-13T04:10:04Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-0cdd68ab4271485bb2da0d1041a02cd62023-06-21T06:55:14ZengElsevierToxicology Reports2214-75002023-01-0110615620Protein and peptide profiles of rats’ organs in scorpion envenomationValery Gunas0Oleksandr Maievskyi1Nataliia Raksha2Tetiana Vovk3Oleksiy Savchuk4Serhii Shchypanskyi5Igor Gunas6Department of Forensic Medicine and Law, National Pirogov Memorial Medical University, Pyrohova Street, 56, Vinnytsia 21018, Ukraine; Corresponding author at: Pyrohova Street, 56, Vinnytsia 21018, Ukraine.Department of Clinical Medicine, Educational and Scientific Center ''Institute of Biology and Medicine'' of Taras Shevchenko National University of Kyiv, Hlushkova Avenue, 2, Kyiv 03127, UkraineDepartment of Biochemistry, Educational and Scientific Center ''Institute of Biology and Medicine'' of Taras Shevchenko National University of Kyiv, Hlushkova Avenue, 2, Kyiv 03127, UkraineDepartment of Clinical Medicine, Educational and Scientific Center ''Institute of Biology and Medicine'' of Taras Shevchenko National University of Kyiv, Hlushkova Avenue, 2, Kyiv 03127, UkraineDepartment of Forensic Medicine and Law, National Pirogov Memorial Medical University, Pyrohova Street, 56, Vinnytsia 21018, UkraineDepartment of Biochemistry, Educational and Scientific Center ''Institute of Biology and Medicine'' of Taras Shevchenko National University of Kyiv, Hlushkova Avenue, 2, Kyiv 03127, UkraineDepartment of Human anatomy, National Pirogov Memorial Medical University, Pyrohova Street, 56, Vinnytsia 21018, UkraineProblem of scorpion envenomation becomes more alarming each year. Main effects of scorpion venom are commonly believed to be related to its neurotoxic properties, yet severe symptoms may also be developed due to the uncontrolled enzymatic activity and formation of various bioactive molecules, including middle-mass molecules (MMMs). MMMs are considered as endogenous intoxication markers, their presence may indicate multiple organ failure. Scorpions, belong to the Leiurus macroctenus species, are very dangerous, nevertheless, effects of their venom on protein and peptide composition within the tissues remains unclear. In this work we have focused the attention on changes in protein and MMM levels and peptide composition in various organs during Leiurus macroctenus envenomation. The results revealed a decrease in protein level during envenomation as well as a significant increment of MMM210 and MMM254 levels in all assessed organs. Quantitative and qualitative compositions of various protein and peptide factions were continually changing. All of this may suggest that Leiurus macroctenus sting causes considerable destruction of cell microenvironment across all essential organs, providing systemic envenomation. In addition, MMM level increment may indicate endogenous intoxication development. Peptides, formed during envenomation, may possess various bioactive properties, analysis of which constitutes an area of further studies.http://www.sciencedirect.com/science/article/pii/S2214750023000604ScorpionismVenomLeiurus genusMiddle-mass molecules |
| spellingShingle | Valery Gunas Oleksandr Maievskyi Nataliia Raksha Tetiana Vovk Oleksiy Savchuk Serhii Shchypanskyi Igor Gunas Protein and peptide profiles of rats’ organs in scorpion envenomation Toxicology Reports Scorpionism Venom Leiurus genus Middle-mass molecules |
| title | Protein and peptide profiles of rats’ organs in scorpion envenomation |
| title_full | Protein and peptide profiles of rats’ organs in scorpion envenomation |
| title_fullStr | Protein and peptide profiles of rats’ organs in scorpion envenomation |
| title_full_unstemmed | Protein and peptide profiles of rats’ organs in scorpion envenomation |
| title_short | Protein and peptide profiles of rats’ organs in scorpion envenomation |
| title_sort | protein and peptide profiles of rats organs in scorpion envenomation |
| topic | Scorpionism Venom Leiurus genus Middle-mass molecules |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023000604 |
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