Expression pattern of non-coding RNAs in non-functioning pituitary adenoma
Non-functioning pituitary adenoma (NFPA) is a benign tumor arising from the adenohypophyseal cells. They can be associated with symptoms arising from mass effect. Although these tumors are regarded to be benign tumors, they are associated with increased comorbidity and mortality. Several studies hav...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.978016/full |
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| author | Soudeh Ghafouri-Fard Arash Safarzadeh Mehdi Akhavan-Bahabadi Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Nader Akbari Dilmaghani |
| author_facet | Soudeh Ghafouri-Fard Arash Safarzadeh Mehdi Akhavan-Bahabadi Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Nader Akbari Dilmaghani |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Non-functioning pituitary adenoma (NFPA) is a benign tumor arising from the adenohypophyseal cells. They can be associated with symptoms arising from mass effect. Although these tumors are regarded to be benign tumors, they are associated with increased comorbidity and mortality. Several studies have indicated abnormal expression of genes in these tumors. In the current study, we have used existing methods to identify differentially expressed genes (DEGs) including DE long non-coding RNAs (DElncRNAs) and DE microRNAs (DEmiRNAs) in NFPAs compared with normal samples. Then, we have assessed the relation between these genes and important signaling pathways. Our analyses led to identification of 3131 DEGs, including 189 downregulated DEGs (such as RPS4Y1 and DDX3Y) and 2898 upregulated DEGs (such as ASB3 and DRD4), and 44 DElncRNAs, including 8 downregulated DElncRNAs (such as NUTM2B-AS1 and MALAT1) and 36 upregulated DElncRNAs (such as BCAR4 and SRD5A3-AS1). GnRH signaling pathway, Tight junction, Gap junction, Melanogenesis, DNA replication, Nucleotide excision repair, Mismatch repair and N-Glycan biosynthesis have been among dysregulated pathways in NFPAs. Taken together, our study has revealed differential expression of several genes and signaling pathways in this type of tumors. |
| first_indexed | 2024-04-12T19:59:38Z |
| format | Article |
| id | doaj.art-0ce0a23e710f4673b5a0a03f44cb48ab |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T19:59:38Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0ce0a23e710f4673b5a0a03f44cb48ab2022-12-22T03:18:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.978016978016Expression pattern of non-coding RNAs in non-functioning pituitary adenomaSoudeh Ghafouri-Fard0Arash Safarzadeh1Mehdi Akhavan-Bahabadi2Bashdar Mahmud Hussen3Bashdar Mahmud Hussen4Mohammad Taheri5Mohammad Taheri6Nader Akbari Dilmaghani7Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranUniversity of Tehran, Tehran, IranDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, IraqCenter of Research and Strategic Studies, Lebanese French University, Erbil, IraqUrology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranInstitute of Human Genetics, Jena University Hospital, Jena, GermanySkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranNon-functioning pituitary adenoma (NFPA) is a benign tumor arising from the adenohypophyseal cells. They can be associated with symptoms arising from mass effect. Although these tumors are regarded to be benign tumors, they are associated with increased comorbidity and mortality. Several studies have indicated abnormal expression of genes in these tumors. In the current study, we have used existing methods to identify differentially expressed genes (DEGs) including DE long non-coding RNAs (DElncRNAs) and DE microRNAs (DEmiRNAs) in NFPAs compared with normal samples. Then, we have assessed the relation between these genes and important signaling pathways. Our analyses led to identification of 3131 DEGs, including 189 downregulated DEGs (such as RPS4Y1 and DDX3Y) and 2898 upregulated DEGs (such as ASB3 and DRD4), and 44 DElncRNAs, including 8 downregulated DElncRNAs (such as NUTM2B-AS1 and MALAT1) and 36 upregulated DElncRNAs (such as BCAR4 and SRD5A3-AS1). GnRH signaling pathway, Tight junction, Gap junction, Melanogenesis, DNA replication, Nucleotide excision repair, Mismatch repair and N-Glycan biosynthesis have been among dysregulated pathways in NFPAs. Taken together, our study has revealed differential expression of several genes and signaling pathways in this type of tumors.https://www.frontiersin.org/articles/10.3389/fonc.2022.978016/fullnon-functioning pituitary adenomalncRNAmiRNAexpressionbiomarker |
| spellingShingle | Soudeh Ghafouri-Fard Arash Safarzadeh Mehdi Akhavan-Bahabadi Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Mohammad Taheri Nader Akbari Dilmaghani Expression pattern of non-coding RNAs in non-functioning pituitary adenoma Frontiers in Oncology non-functioning pituitary adenoma lncRNA miRNA expression biomarker |
| title | Expression pattern of non-coding RNAs in non-functioning pituitary adenoma |
| title_full | Expression pattern of non-coding RNAs in non-functioning pituitary adenoma |
| title_fullStr | Expression pattern of non-coding RNAs in non-functioning pituitary adenoma |
| title_full_unstemmed | Expression pattern of non-coding RNAs in non-functioning pituitary adenoma |
| title_short | Expression pattern of non-coding RNAs in non-functioning pituitary adenoma |
| title_sort | expression pattern of non coding rnas in non functioning pituitary adenoma |
| topic | non-functioning pituitary adenoma lncRNA miRNA expression biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.978016/full |
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