Visual impairment in aging and cognitive decline: experience in a Memory Clinic
Abstract Visual impairment is common in people living with dementia and regular ophthalmological exams may improve their quality of life. We evaluated visual function in a cohort of elderly individuals and analyzed its association with their degree of cognitive impairment. Participants underwent neu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-45055-9 |
| _version_ | 1818997753172197376 |
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| author | Marta Marquié Miguel Castilla-Martí Sergi Valero Joan Martínez Domingo Sánchez Isabel Hernández Maitée Rosende-Roca Liliana Vargas Ana Mauleón Octavio Rodríguez-Gómez Carla Abdelnour Silvia Gil Miguel A. Santos-Santos Montserrat Alegret Ana Espinosa Gemma Ortega Alba Pérez-Cordón Ángela Sanabria Natalia Roberto Sonia Moreno-Grau Itziar de Rojas Rafael Simó Andreea Ciudin Cristina Hernández Adelina Orellana Gemma Monté-Rubio Alba Benaque Agustín Ruiz Lluís Tárraga Mercè Boada |
| author_facet | Marta Marquié Miguel Castilla-Martí Sergi Valero Joan Martínez Domingo Sánchez Isabel Hernández Maitée Rosende-Roca Liliana Vargas Ana Mauleón Octavio Rodríguez-Gómez Carla Abdelnour Silvia Gil Miguel A. Santos-Santos Montserrat Alegret Ana Espinosa Gemma Ortega Alba Pérez-Cordón Ángela Sanabria Natalia Roberto Sonia Moreno-Grau Itziar de Rojas Rafael Simó Andreea Ciudin Cristina Hernández Adelina Orellana Gemma Monté-Rubio Alba Benaque Agustín Ruiz Lluís Tárraga Mercè Boada |
| author_sort | Marta Marquié |
| collection | DOAJ |
| description | Abstract Visual impairment is common in people living with dementia and regular ophthalmological exams may improve their quality of life. We evaluated visual function in a cohort of elderly individuals and analyzed its association with their degree of cognitive impairment. Participants underwent neurological and neuropsychological exams, neuro-ophthalmological assessment (visual acuity, intraocular pressure, rates of past ophthalmological pathologies, use of ocular correction, treatments and surgeries) and optical coherence tomography (OCT) scan. We analyzed differences in ophthalmological characteristics among diagnostic groups. The final sample of 1746 study participants aged ≥ 50 comprised 229 individuals with Subjective Cognitive Decline (SCD), 695 with mild cognitive impairment (MCI) and 833 with Dementia (Alzheimer disease: n = 660; vascular dementia: n = 92, Lewy body dementia: n = 34; frontotemporal dementia: n = 19 and other: n = 28). Age, gender and education were used as covariates. Patients with Dementia, compared to those with SCD and MCI, presented worse visual acuity (p < 0.001), used less visual correction (p = 0.02 and p < 0.001, respectively) and fewer ophthalmological treatments (p = 0.004 and p < 0.001, respectively) and underwent fewer ocular surgeries (p = 0.009 and p < 0.001, respectively). OCT image quality worsened in parallel to cognitive decline (Dementia vs SCD: p = 0.008; Dementia vs MCI: p < 0.001). No group differences in past ophthalmological disorders or abnormal OCT findings were detected. Efforts should be made to ensure dementia patients undergo regular ophthalmological assessments to correct their visual function in order to improve their quality of life. |
| first_indexed | 2024-12-20T21:50:38Z |
| format | Article |
| id | doaj.art-0ce0b1c095224ed481d85b588f61fae0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:50:38Z |
| publishDate | 2019-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0ce0b1c095224ed481d85b588f61fae02022-12-21T19:25:33ZengNature PortfolioScientific Reports2045-23222019-06-019111010.1038/s41598-019-45055-9Visual impairment in aging and cognitive decline: experience in a Memory ClinicMarta Marquié0Miguel Castilla-Martí1Sergi Valero2Joan Martínez3Domingo Sánchez4Isabel Hernández5Maitée Rosende-Roca6Liliana Vargas7Ana Mauleón8Octavio Rodríguez-Gómez9Carla Abdelnour10Silvia Gil11Miguel A. Santos-Santos12Montserrat Alegret13Ana Espinosa14Gemma Ortega15Alba Pérez-Cordón16Ángela Sanabria17Natalia Roberto18Sonia Moreno-Grau19Itziar de Rojas20Rafael Simó21Andreea Ciudin22Cristina Hernández23Adelina Orellana24Gemma Monté-Rubio25Alba Benaque26Agustín Ruiz27Lluís Tárraga28Mercè Boada29Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Clínica Oftalmológica Dr. CastillaAlzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos IIIAlzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Alzheimer Research Center and Memory Clinic, Fundació ACE Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya (UIC)Abstract Visual impairment is common in people living with dementia and regular ophthalmological exams may improve their quality of life. We evaluated visual function in a cohort of elderly individuals and analyzed its association with their degree of cognitive impairment. Participants underwent neurological and neuropsychological exams, neuro-ophthalmological assessment (visual acuity, intraocular pressure, rates of past ophthalmological pathologies, use of ocular correction, treatments and surgeries) and optical coherence tomography (OCT) scan. We analyzed differences in ophthalmological characteristics among diagnostic groups. The final sample of 1746 study participants aged ≥ 50 comprised 229 individuals with Subjective Cognitive Decline (SCD), 695 with mild cognitive impairment (MCI) and 833 with Dementia (Alzheimer disease: n = 660; vascular dementia: n = 92, Lewy body dementia: n = 34; frontotemporal dementia: n = 19 and other: n = 28). Age, gender and education were used as covariates. Patients with Dementia, compared to those with SCD and MCI, presented worse visual acuity (p < 0.001), used less visual correction (p = 0.02 and p < 0.001, respectively) and fewer ophthalmological treatments (p = 0.004 and p < 0.001, respectively) and underwent fewer ocular surgeries (p = 0.009 and p < 0.001, respectively). OCT image quality worsened in parallel to cognitive decline (Dementia vs SCD: p = 0.008; Dementia vs MCI: p < 0.001). No group differences in past ophthalmological disorders or abnormal OCT findings were detected. Efforts should be made to ensure dementia patients undergo regular ophthalmological assessments to correct their visual function in order to improve their quality of life.https://doi.org/10.1038/s41598-019-45055-9 |
| spellingShingle | Marta Marquié Miguel Castilla-Martí Sergi Valero Joan Martínez Domingo Sánchez Isabel Hernández Maitée Rosende-Roca Liliana Vargas Ana Mauleón Octavio Rodríguez-Gómez Carla Abdelnour Silvia Gil Miguel A. Santos-Santos Montserrat Alegret Ana Espinosa Gemma Ortega Alba Pérez-Cordón Ángela Sanabria Natalia Roberto Sonia Moreno-Grau Itziar de Rojas Rafael Simó Andreea Ciudin Cristina Hernández Adelina Orellana Gemma Monté-Rubio Alba Benaque Agustín Ruiz Lluís Tárraga Mercè Boada Visual impairment in aging and cognitive decline: experience in a Memory Clinic Scientific Reports |
| title | Visual impairment in aging and cognitive decline: experience in a Memory Clinic |
| title_full | Visual impairment in aging and cognitive decline: experience in a Memory Clinic |
| title_fullStr | Visual impairment in aging and cognitive decline: experience in a Memory Clinic |
| title_full_unstemmed | Visual impairment in aging and cognitive decline: experience in a Memory Clinic |
| title_short | Visual impairment in aging and cognitive decline: experience in a Memory Clinic |
| title_sort | visual impairment in aging and cognitive decline experience in a memory clinic |
| url | https://doi.org/10.1038/s41598-019-45055-9 |
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