Comprehensive mapping of exon junction complex binding sites reveals universal EJC deposition in Drosophila

Comprehensive mapping of exon junction complex binding sites reveals universal EJC deposition in Drosophila

Abstract Background The exon junction complex (EJC) is involved in most steps of the mRNA life cycle, ranging from splicing to nonsense-mediated mRNA decay (NMD). It is assembled by the splicing machinery onto mRNA in a sequence-independent manner. A fundamental open question is whether the EJC is d...

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Bibliographic Details
Main Authors: Lucía Morillo, Toni Paternina, Quentin Alasseur, Auguste Genovesio, Schraga Schwartz, Hervé Le Hir
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Biology
Subjects:
Exon junction complex
eCLIP
RBPs
mRNP
RNA-protein interaction
Transcriptome-wide mapping
Online Access:https://doi.org/10.1186/s12915-023-01749-1

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