The recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells

The recombinant l-lysine α-oxidase from the fungus Trichoderma harzianum promotes apoptosis and necrosis of leukemia CD34 + hematopoietic cells

Abstract Background In hematologic cancers, including leukemia, cells depend on amino acids for rapid growth. Anti-metabolites that prevent their synthesis or promote their degradation are considered potential cancer treatment agents. Amino acid deprivation triggers proliferation inhibition, autopha...

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Main Authors: Mariana do Nascimento Costa, Thiago Aparecido Silva, Dimitrius Santiago Passos Simões Fróes Guimarães, Rafael Ricci-Azevedo, Felipe Roberti Teixeira, Leonardo Reis Silveira, Marcelo Damário Gomes, Vítor Marcel Faça, Eduardo Brandt de Oliveira, Rodrigo T. Calado, Roberto N. Silva
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Microbial Cell Factories
Subjects:
Leukemia
l-lysine α-oxidase
Trichoderma harzianum
Cancer treatment
Online Access:https://doi.org/10.1186/s12934-024-02315-2

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