Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14922 |
| _version_ | 1828972953739460608 |
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| author | Haikuo Zhang Christine Fillmore Brainson Shohei Koyama Amanda J. Redig Ting Chen Shuai Li Manav Gupta Carolina Garcia-de-Alba Margherita Paschini Grit S. Herter-Sprie Gang Lu Xin Zhang Bryan P. Marsh Stephanie J. Tuminello Chunxiao Xu Zhao Chen Xiaoen Wang Esra A. Akbay Mei Zheng Sangeetha Palakurthi Lynette M. Sholl Anil K. Rustgi David J. Kwiatkowski J Alan Diehl Adam J. Bass Norman E. Sharpless Glenn Dranoff Peter S. Hammerman Hongbin Ji Nabeel Bardeesy Dieter Saur Hideo Watanabe Carla F. Kim Kwok-Kin Wong |
| author_facet | Haikuo Zhang Christine Fillmore Brainson Shohei Koyama Amanda J. Redig Ting Chen Shuai Li Manav Gupta Carolina Garcia-de-Alba Margherita Paschini Grit S. Herter-Sprie Gang Lu Xin Zhang Bryan P. Marsh Stephanie J. Tuminello Chunxiao Xu Zhao Chen Xiaoen Wang Esra A. Akbay Mei Zheng Sangeetha Palakurthi Lynette M. Sholl Anil K. Rustgi David J. Kwiatkowski J Alan Diehl Adam J. Bass Norman E. Sharpless Glenn Dranoff Peter S. Hammerman Hongbin Ji Nabeel Bardeesy Dieter Saur Hideo Watanabe Carla F. Kim Kwok-Kin Wong |
| author_sort | Haikuo Zhang |
| collection | DOAJ |
| description | The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous differentiation genes. |
| first_indexed | 2024-12-14T13:37:33Z |
| format | Article |
| id | doaj.art-0ce62822a53e4bae828250fb78660d57 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:37:33Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0ce62822a53e4bae828250fb78660d572022-12-21T22:59:32ZengNature PortfolioNature Communications2041-17232017-04-018111510.1038/ncomms14922Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2Haikuo Zhang0Christine Fillmore Brainson1Shohei Koyama2Amanda J. Redig3Ting Chen4Shuai Li5Manav Gupta6Carolina Garcia-de-Alba7Margherita Paschini8Grit S. Herter-Sprie9Gang Lu10Xin Zhang11Bryan P. Marsh12Stephanie J. Tuminello13Chunxiao Xu14Zhao Chen15Xiaoen Wang16Esra A. Akbay17Mei Zheng18Sangeetha Palakurthi19Lynette M. Sholl20Anil K. Rustgi21David J. Kwiatkowski22J Alan Diehl23Adam J. Bass24Norman E. Sharpless25Glenn Dranoff26Peter S. Hammerman27Hongbin Ji28Nabeel Bardeesy29Dieter Saur30Hideo Watanabe31Carla F. Kim32Kwok-Kin Wong33Department of Medical Oncology, Dana-Farber Cancer InstituteStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital BostonDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital BostonStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital BostonStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital BostonDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital BostonDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine; Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolBelfer Institute for Applied Cancer Science, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteDivision of Gastroenterology, Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Abramson Cancer CenterDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Biochemical and Molecular Biology, Medical University of South CarolinaDepartment of Medical Oncology, Dana-Farber Cancer InstituteUniversity of North Carolina Lineberger Comprehensive Cancer Center, UNC School of MedicineDepartment of Medical Oncology, Dana-Farber Cancer InstituteDepartment of Medical Oncology, Dana-Farber Cancer InstituteKey Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesCancer Center, Massachusetts General HospitalDepartment of Internal Medicine II, Klinikum rechts der Isar, Technische Universität MünchenBelfer Institute for Applied Cancer Science, Dana-Farber Cancer InstituteStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital BostonDepartment of Medical Oncology, Dana-Farber Cancer InstituteThe mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chromatin changes that lead to expression of squamous differentiation genes.https://doi.org/10.1038/ncomms14922 |
| spellingShingle | Haikuo Zhang Christine Fillmore Brainson Shohei Koyama Amanda J. Redig Ting Chen Shuai Li Manav Gupta Carolina Garcia-de-Alba Margherita Paschini Grit S. Herter-Sprie Gang Lu Xin Zhang Bryan P. Marsh Stephanie J. Tuminello Chunxiao Xu Zhao Chen Xiaoen Wang Esra A. Akbay Mei Zheng Sangeetha Palakurthi Lynette M. Sholl Anil K. Rustgi David J. Kwiatkowski J Alan Diehl Adam J. Bass Norman E. Sharpless Glenn Dranoff Peter S. Hammerman Hongbin Ji Nabeel Bardeesy Dieter Saur Hideo Watanabe Carla F. Kim Kwok-Kin Wong Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 Nature Communications |
| title | Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
| title_full | Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
| title_fullStr | Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
| title_full_unstemmed | Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
| title_short | Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2 |
| title_sort | lkb1 inactivation drives lung cancer lineage switching governed by polycomb repressive complex 2 |
| url | https://doi.org/10.1038/ncomms14922 |
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