The Implication of Gastric Microbiome in the Treatment of Gastric Cancer
Gastric cancer (GC) is one of the most common and deadly malignancies worldwide. Helicobacter pylori have been documented as a risk factor for GC. The development of sequencing technology has broadened the knowledge of the gastric microbiome, which is essential in maintaining homeostasis. Recent stu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/8/2039 |
| _version_ | 1797436450936979456 |
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| author | George Pappas-Gogos Kostas Tepelenis Fotis Fousekis Konstantinos Katsanos Michail Pitiakoudis Konstantinos Vlachos |
| author_facet | George Pappas-Gogos Kostas Tepelenis Fotis Fousekis Konstantinos Katsanos Michail Pitiakoudis Konstantinos Vlachos |
| author_sort | George Pappas-Gogos |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the most common and deadly malignancies worldwide. Helicobacter pylori have been documented as a risk factor for GC. The development of sequencing technology has broadened the knowledge of the gastric microbiome, which is essential in maintaining homeostasis. Recent studies have demonstrated the involvement of the gastric microbiome in the development of GC. Therefore, the elucidation of the mechanism by which the gastric microbiome contributes to the development and progression of GC may improve GC’s prevention, diagnosis, and treatment. In this review, we discuss the current knowledge about changes in gastric microbial composition in GC patients, their role in carcinogenesis, the possible therapeutic role of the gastric microbiome, and its implications for current GC therapy. |
| first_indexed | 2024-03-09T11:02:45Z |
| format | Article |
| id | doaj.art-0ce68f6393564ecca2367abd0b298081 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T11:02:45Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0ce68f6393564ecca2367abd0b2980812023-12-01T01:09:26ZengMDPI AGCancers2072-66942022-04-01148203910.3390/cancers14082039The Implication of Gastric Microbiome in the Treatment of Gastric CancerGeorge Pappas-Gogos0Kostas Tepelenis1Fotis Fousekis2Konstantinos Katsanos3Michail Pitiakoudis4Konstantinos Vlachos5Department of Surgery, University Hospital of Ioannina, 45500 Ioannina, GreeceDepartment of Surgery, University Hospital of Ioannina, 45500 Ioannina, GreeceDepartment of Gastroenterology, University Hospital of Ioannina, 45500 Ioannina, GreeceDepartment of Gastroenterology, University Hospital of Ioannina, 45500 Ioannina, GreeceDepartment of Surgery, University Hospital of Alexandroupolis, 68100 Alexandroupolis, GreeceDepartment of Surgery, University Hospital of Ioannina, 45500 Ioannina, GreeceGastric cancer (GC) is one of the most common and deadly malignancies worldwide. Helicobacter pylori have been documented as a risk factor for GC. The development of sequencing technology has broadened the knowledge of the gastric microbiome, which is essential in maintaining homeostasis. Recent studies have demonstrated the involvement of the gastric microbiome in the development of GC. Therefore, the elucidation of the mechanism by which the gastric microbiome contributes to the development and progression of GC may improve GC’s prevention, diagnosis, and treatment. In this review, we discuss the current knowledge about changes in gastric microbial composition in GC patients, their role in carcinogenesis, the possible therapeutic role of the gastric microbiome, and its implications for current GC therapy.https://www.mdpi.com/2072-6694/14/8/2039gastric cancergastric microbiomechemotherapyimmunotherapy |
| spellingShingle | George Pappas-Gogos Kostas Tepelenis Fotis Fousekis Konstantinos Katsanos Michail Pitiakoudis Konstantinos Vlachos The Implication of Gastric Microbiome in the Treatment of Gastric Cancer Cancers gastric cancer gastric microbiome chemotherapy immunotherapy |
| title | The Implication of Gastric Microbiome in the Treatment of Gastric Cancer |
| title_full | The Implication of Gastric Microbiome in the Treatment of Gastric Cancer |
| title_fullStr | The Implication of Gastric Microbiome in the Treatment of Gastric Cancer |
| title_full_unstemmed | The Implication of Gastric Microbiome in the Treatment of Gastric Cancer |
| title_short | The Implication of Gastric Microbiome in the Treatment of Gastric Cancer |
| title_sort | implication of gastric microbiome in the treatment of gastric cancer |
| topic | gastric cancer gastric microbiome chemotherapy immunotherapy |
| url | https://www.mdpi.com/2072-6694/14/8/2039 |
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