Targeting Adiponectin in Breast Cancer
Obesity and breast cancer are two major health issues that could be categorized as sincere threats to human health. In the last few decades, the relationship between obesity and cancer has been well established and extensively investigated. There is strong evidence that overweight and obesity increa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/11/2958 |
| _version_ | 1797465821044277248 |
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| author | Rawan Nehme Mona Diab-Assaf Caroline Decombat Laetitia Delort Florence Caldefie-Chezet |
| author_facet | Rawan Nehme Mona Diab-Assaf Caroline Decombat Laetitia Delort Florence Caldefie-Chezet |
| author_sort | Rawan Nehme |
| collection | DOAJ |
| description | Obesity and breast cancer are two major health issues that could be categorized as sincere threats to human health. In the last few decades, the relationship between obesity and cancer has been well established and extensively investigated. There is strong evidence that overweight and obesity increase the risk of postmenopausal breast cancer, and adipokines are the central players in this relationship. Produced and secreted predominantly by white adipose tissue, adiponectin is a bioactive molecule that exhibits numerous protective effects and is considered the guardian angel of adipokine. In the obesity–cancer relationship, more and more evidence shows that adiponectin may prevent and protect individuals from developing breast cancer. Recently, several updates have been published on the implication of adiponectin in regulating tumor development, progression, and metastases. In this review, we provide an updated overview of the metabolic signaling linking adiponectin and breast cancer in all its stages. On the other hand, we critically summarize all the available promising candidates that may reactivate these pathways mainly by targeting adiponectin receptors. These molecules could be synthetic small molecules or plant-based proteins. Interestingly, the advances in genomics have made it possible to create peptide sequences that could specifically replace human adiponectin, activate its receptor, and mimic its function. Thus, the obvious anti-cancer activity of adiponectin on breast cancer should be better exploited, and adiponectin must be regarded as a serious biomarker that should be targeted in order to confront this threatening disease. |
| first_indexed | 2024-03-09T18:27:00Z |
| format | Article |
| id | doaj.art-0ce6fbf8221e4f29aa2180e30e0e7297 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T18:27:00Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0ce6fbf8221e4f29aa2180e30e0e72972023-11-24T07:46:48ZengMDPI AGBiomedicines2227-90592022-11-011011295810.3390/biomedicines10112958Targeting Adiponectin in Breast CancerRawan Nehme0Mona Diab-Assaf1Caroline Decombat2Laetitia Delort3Florence Caldefie-Chezet4Université Clermont-Auvergne, INRAE, UNH Unité de Nutrition Humaine, CRNH-Auvergne, 63000 Clermont-Ferrand, FranceEquipe Tumorigénèse Moléculaire et Pharmacologie Anticancéreuse, Faculté des Sciences II, Université Libanaise Fanar, Beyrouth 1500, LebanonUniversité Clermont-Auvergne, INRAE, UNH Unité de Nutrition Humaine, CRNH-Auvergne, 63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRAE, UNH Unité de Nutrition Humaine, CRNH-Auvergne, 63000 Clermont-Ferrand, FranceUniversité Clermont-Auvergne, INRAE, UNH Unité de Nutrition Humaine, CRNH-Auvergne, 63000 Clermont-Ferrand, FranceObesity and breast cancer are two major health issues that could be categorized as sincere threats to human health. In the last few decades, the relationship between obesity and cancer has been well established and extensively investigated. There is strong evidence that overweight and obesity increase the risk of postmenopausal breast cancer, and adipokines are the central players in this relationship. Produced and secreted predominantly by white adipose tissue, adiponectin is a bioactive molecule that exhibits numerous protective effects and is considered the guardian angel of adipokine. In the obesity–cancer relationship, more and more evidence shows that adiponectin may prevent and protect individuals from developing breast cancer. Recently, several updates have been published on the implication of adiponectin in regulating tumor development, progression, and metastases. In this review, we provide an updated overview of the metabolic signaling linking adiponectin and breast cancer in all its stages. On the other hand, we critically summarize all the available promising candidates that may reactivate these pathways mainly by targeting adiponectin receptors. These molecules could be synthetic small molecules or plant-based proteins. Interestingly, the advances in genomics have made it possible to create peptide sequences that could specifically replace human adiponectin, activate its receptor, and mimic its function. Thus, the obvious anti-cancer activity of adiponectin on breast cancer should be better exploited, and adiponectin must be regarded as a serious biomarker that should be targeted in order to confront this threatening disease.https://www.mdpi.com/2227-9059/10/11/2958adiponectinbreast cancerobesityadiponectin receptor agonistsmolecular pathwaysadiponectin-focused therapeutics |
| spellingShingle | Rawan Nehme Mona Diab-Assaf Caroline Decombat Laetitia Delort Florence Caldefie-Chezet Targeting Adiponectin in Breast Cancer Biomedicines adiponectin breast cancer obesity adiponectin receptor agonists molecular pathways adiponectin-focused therapeutics |
| title | Targeting Adiponectin in Breast Cancer |
| title_full | Targeting Adiponectin in Breast Cancer |
| title_fullStr | Targeting Adiponectin in Breast Cancer |
| title_full_unstemmed | Targeting Adiponectin in Breast Cancer |
| title_short | Targeting Adiponectin in Breast Cancer |
| title_sort | targeting adiponectin in breast cancer |
| topic | adiponectin breast cancer obesity adiponectin receptor agonists molecular pathways adiponectin-focused therapeutics |
| url | https://www.mdpi.com/2227-9059/10/11/2958 |
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