Birth weight and coronary artery disease. The effect of gender and diabetes
<p>Background: The developmental origin theory of coronary heart disease proposes that undernutrition in utero permanently changes body functions and metabolism leading to an increased risk of coronary artery diseases (CAD) in adult life. Some studies support this theory but others suggest tha...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2009-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v05p0244.htm |
| _version_ | 1828354667434737664 |
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| author | Maria Banci, Patrizia Saccucci, Alessandro Dofcaci, Ilaria Sansoni, Andrea Magrini, Egidio Bottini, Fulvia Gloria-Bottini |
| author_facet | Maria Banci, Patrizia Saccucci, Alessandro Dofcaci, Ilaria Sansoni, Andrea Magrini, Egidio Bottini, Fulvia Gloria-Bottini |
| author_sort | Maria Banci, Patrizia Saccucci, Alessandro Dofcaci, Ilaria Sansoni, Andrea Magrini, Egidio Bottini, Fulvia Gloria-Bottini |
| collection | DOAJ |
| description | <p>Background: The developmental origin theory of coronary heart disease proposes that undernutrition in utero permanently changes body functions and metabolism leading to an increased risk of coronary artery diseases (CAD) in adult life. Some studies support this theory but others suggest that birth weight (BW) is not a major risk factor for cardiovascular diseases. Gender differences concerning the association between BW and risk factors for CAD have been reported in some studies but not in others.</p> <p>In this paper we have analyzed the effect of gender and diabetes on the relationship between BW and CAD in the White population of Rome.</p> <p>Material and Methods: 226 subjects admitted to the Hospital for non fatal CAD from the White population of Rome were studied. 395 consecutive newborn infants studied in the same population in the years 1968-1972 were considered for comparison.</p> <p>Results: Among subjects with CAD, reliable information on BW was obtained in 127 subjects. The distribution of BW in CAD depends on gender (p=0.009). In females with CAD there is a tendency toward low BW, while in males with CAD there is a tendency toward high BW. These associations are very marked in non-diabetic subjects with CAD (p=.001), while no significant association is observed in diabetic subjects (p=0.557).</p> <p>Conclusion: Our data confirm the association between BW and CAD and suggest that the association depends on gender and is influenced by diabetes.</p> |
| first_indexed | 2024-04-14T02:28:25Z |
| format | Article |
| id | doaj.art-0ce707876e9249aba244798f32c5f5f2 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-04-14T02:28:25Z |
| publishDate | 2009-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-0ce707876e9249aba244798f32c5f5f22022-12-22T02:17:46ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882009-01-0153244248Birth weight and coronary artery disease. The effect of gender and diabetesMaria Banci, Patrizia Saccucci, Alessandro Dofcaci, Ilaria Sansoni, Andrea Magrini, Egidio Bottini, Fulvia Gloria-Bottini<p>Background: The developmental origin theory of coronary heart disease proposes that undernutrition in utero permanently changes body functions and metabolism leading to an increased risk of coronary artery diseases (CAD) in adult life. Some studies support this theory but others suggest that birth weight (BW) is not a major risk factor for cardiovascular diseases. Gender differences concerning the association between BW and risk factors for CAD have been reported in some studies but not in others.</p> <p>In this paper we have analyzed the effect of gender and diabetes on the relationship between BW and CAD in the White population of Rome.</p> <p>Material and Methods: 226 subjects admitted to the Hospital for non fatal CAD from the White population of Rome were studied. 395 consecutive newborn infants studied in the same population in the years 1968-1972 were considered for comparison.</p> <p>Results: Among subjects with CAD, reliable information on BW was obtained in 127 subjects. The distribution of BW in CAD depends on gender (p=0.009). In females with CAD there is a tendency toward low BW, while in males with CAD there is a tendency toward high BW. These associations are very marked in non-diabetic subjects with CAD (p=.001), while no significant association is observed in diabetic subjects (p=0.557).</p> <p>Conclusion: Our data confirm the association between BW and CAD and suggest that the association depends on gender and is influenced by diabetes.</p>http://www.biolsci.org/v05p0244.htm |
| spellingShingle | Maria Banci, Patrizia Saccucci, Alessandro Dofcaci, Ilaria Sansoni, Andrea Magrini, Egidio Bottini, Fulvia Gloria-Bottini Birth weight and coronary artery disease. The effect of gender and diabetes International Journal of Biological Sciences |
| title | Birth weight and coronary artery disease. The effect of gender and diabetes |
| title_full | Birth weight and coronary artery disease. The effect of gender and diabetes |
| title_fullStr | Birth weight and coronary artery disease. The effect of gender and diabetes |
| title_full_unstemmed | Birth weight and coronary artery disease. The effect of gender and diabetes |
| title_short | Birth weight and coronary artery disease. The effect of gender and diabetes |
| title_sort | birth weight and coronary artery disease the effect of gender and diabetes |
| url | http://www.biolsci.org/v05p0244.htm |
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