Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature
<p>Abstract</p> <p>Previously, the majority of the human genome was thought to be 'junk' DNA with no functional purpose. Over the past decade, the field of RNA research has rapidly expanded, with a concomitant increase in the number of non-protein coding RNA (ncRNA) genes...
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| Format: | Article |
| Language: | English |
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BMC
2011-01-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://www.humgenomics.com/content/5/2/90 |
| _version_ | 1798037692197371904 |
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| author | Wright Mathew W Bruford Elspeth A |
| author_facet | Wright Mathew W Bruford Elspeth A |
| author_sort | Wright Mathew W |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Previously, the majority of the human genome was thought to be 'junk' DNA with no functional purpose. Over the past decade, the field of RNA research has rapidly expanded, with a concomitant increase in the number of non-protein coding RNA (ncRNA) genes identified in this 'junk'. Many of the encoded ncRNAs have already been shown to be essential for a variety of vital functions, and this wealth of annotated human ncRNAs requires standardised naming in order to aid effective communication. The HUGO Gene Nomenclature Committee (HGNC) is the only organisation authorised to assign standardised nomenclature to human genes. Of the 30,000 approved gene symbols currently listed in the HGNC database (<url>http://www.genenames.org/search</url>), the majority represent protein-coding genes; however, they also include pseudogenes, phenotypic loci and some genomic features. In recent years the list has also increased to include almost 3,000 named human ncRNA genes. HGNC is actively engaging with the RNA research community in order to provide unique symbols and names for each sequence that encodes an ncRNA. Most of the classical small ncRNA genes have now been provided with a unique nomenclature, and work on naming the long (> 200 nucleotides) non-coding RNAs (lncRNAs) is ongoing.</p> |
| first_indexed | 2024-04-11T21:30:00Z |
| format | Article |
| id | doaj.art-0ce8ba27300f41f2944d1b31ae1e9eab |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-11T21:30:00Z |
| publishDate | 2011-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-0ce8ba27300f41f2944d1b31ae1e9eab2022-12-22T04:02:01ZengBMCHuman Genomics1479-73642011-01-0152909810.1186/1479-7364-5-2-90Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclatureWright Mathew WBruford Elspeth A<p>Abstract</p> <p>Previously, the majority of the human genome was thought to be 'junk' DNA with no functional purpose. Over the past decade, the field of RNA research has rapidly expanded, with a concomitant increase in the number of non-protein coding RNA (ncRNA) genes identified in this 'junk'. Many of the encoded ncRNAs have already been shown to be essential for a variety of vital functions, and this wealth of annotated human ncRNAs requires standardised naming in order to aid effective communication. The HUGO Gene Nomenclature Committee (HGNC) is the only organisation authorised to assign standardised nomenclature to human genes. Of the 30,000 approved gene symbols currently listed in the HGNC database (<url>http://www.genenames.org/search</url>), the majority represent protein-coding genes; however, they also include pseudogenes, phenotypic loci and some genomic features. In recent years the list has also increased to include almost 3,000 named human ncRNA genes. HGNC is actively engaging with the RNA research community in order to provide unique symbols and names for each sequence that encodes an ncRNA. Most of the classical small ncRNA genes have now been provided with a unique nomenclature, and work on naming the long (> 200 nucleotides) non-coding RNAs (lncRNAs) is ongoing.</p>http://www.humgenomics.com/content/5/2/90ncRNARNAnomenclaturenon-protein coding |
| spellingShingle | Wright Mathew W Bruford Elspeth A Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature Human Genomics ncRNA RNA nomenclature non-protein coding |
| title | Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature |
| title_full | Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature |
| title_fullStr | Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature |
| title_full_unstemmed | Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature |
| title_short | Naming 'junk': Human non-protein coding RNA (ncRNA) gene nomenclature |
| title_sort | naming junk human non protein coding rna ncrna gene nomenclature |
| topic | ncRNA RNA nomenclature non-protein coding |
| url | http://www.humgenomics.com/content/5/2/90 |
| work_keys_str_mv | AT wrightmatheww namingjunkhumannonproteincodingrnancrnagenenomenclature AT brufordelspetha namingjunkhumannonproteincodingrnancrnagenenomenclature |