Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines

Inhibition of Heme Export and/or Heme Synthesis Potentiates Metformin Anti-Proliferative Effect on Cancer Cell Lines

Cancer is one of the leading causes of mortality worldwide. Beyond standard therapeutic options, whose effectiveness is often reduced by drug resistance, repurposing of the antidiabetic drug metformin appears promising. Heme metabolism plays a pivotal role in the control of metabolic adaptations tha...

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Bibliographic Details
Main Authors: Anna Lucia Allocco, Francesca Bertino, Sara Petrillo, Deborah Chiabrando, Chiara Riganti, Alberto Bardelli, Fiorella Altruda, Veronica Fiorito, Emanuela Tolosano
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
heme
cancer
FLVCR1
FLVCR1a
ALAS1
metformin
Online Access:https://www.mdpi.com/2072-6694/14/5/1230

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