A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China
The Qiang ethnic group is one of the oldest ethnic groups in China and is the most active ethnic group among all the populations along the Tibetan-Yi corridor. They have had a profound impact nationally and internationally. The paternal and maternal genetic feature of the Qiang ethnic group has been...
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Elsevier
2023-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402309031X |
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| author | Zefei Wang Mengyuan Song Qiang Lyu Jun Ying Qian Wu Feng Song Lanrui Jiang Xiaowen Wei Shuangshuang Wang Fei Wang Yuxiang Zhou Xingbo Song Haibo Luo |
| author_facet | Zefei Wang Mengyuan Song Qiang Lyu Jun Ying Qian Wu Feng Song Lanrui Jiang Xiaowen Wei Shuangshuang Wang Fei Wang Yuxiang Zhou Xingbo Song Haibo Luo |
| author_sort | Zefei Wang |
| collection | DOAJ |
| description | The Qiang ethnic group is one of the oldest ethnic groups in China and is the most active ethnic group among all the populations along the Tibetan-Yi corridor. They have had a profound impact nationally and internationally. The paternal and maternal genetic feature of the Qiang ethnic group has been revealed, leaving the question of the genetic characteristics from autosomes and X chromosome not answered. The aim of this study was to explore the potential of 36 A-STR (Microreader™ 36A ID System) and 19 X-STR (Microreader™ 19X System) for application in the Qiang population and to elucidate their genetic diversity in southwest China. The cumulative probability of exclusion (CPE) for autosomal STRs is 1–1.3814 × 10−15 and the mean paternity exclusion chance (MEC) for X-STRs is 1–1.7323 × 10−6. Forensic parameters suggest that the STRs analyzed here are well-suited for forensic applications. The results of phylogenetic, interpopulation differentiation, and principal coordinates analysis (PCoA) indicate that the Qiang people have extensive connections with ethnic minorities in China, supporting the view that the Qiang people are the oldest group in the entire Sino-Tibetan language family. The Qiang appeared genetically more associated with most ethnic groups in China, especially the Han. The calculation of random matching probability (RMP) was improved by Fst correction of allele frequencies to make RMP more accurate and reasonable. This study can fill in the gaps in the Qiang STR reference database, providing valuable frequency data for forensic applications and evidence for the Qiang's genetic pattern as an important ancestral position in the Sino-Tibetan populations. |
| first_indexed | 2024-03-09T09:17:26Z |
| format | Article |
| id | doaj.art-0ceabf94b2d44d66a30d7d1ddc92fc7c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:17:26Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-0ceabf94b2d44d66a30d7d1ddc92fc7c2023-12-02T07:04:22ZengElsevierHeliyon2405-84402023-11-01911e21823A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of ChinaZefei Wang0Mengyuan Song1Qiang Lyu2Jun Ying3Qian Wu4Feng Song5Lanrui Jiang6Xiaowen Wei7Shuangshuang Wang8Fei Wang9Yuxiang Zhou10Xingbo Song11Haibo Luo12Department of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Clinical Laboratory, People's Hospital of Beichuan Qiang Autonomous County, Beichuan, 622750, ChinaDepartment of Clinical Laboratory, Santai People's Hospital, Santai, 621100, ChinaDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, 430060, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, ChinaDepartment of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Corresponding author. Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, China.Department of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, China; Corresponding author. Department of Forensic Genetics, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, No. 3-16 Renmin South Road, Chengdu, China.The Qiang ethnic group is one of the oldest ethnic groups in China and is the most active ethnic group among all the populations along the Tibetan-Yi corridor. They have had a profound impact nationally and internationally. The paternal and maternal genetic feature of the Qiang ethnic group has been revealed, leaving the question of the genetic characteristics from autosomes and X chromosome not answered. The aim of this study was to explore the potential of 36 A-STR (Microreader™ 36A ID System) and 19 X-STR (Microreader™ 19X System) for application in the Qiang population and to elucidate their genetic diversity in southwest China. The cumulative probability of exclusion (CPE) for autosomal STRs is 1–1.3814 × 10−15 and the mean paternity exclusion chance (MEC) for X-STRs is 1–1.7323 × 10−6. Forensic parameters suggest that the STRs analyzed here are well-suited for forensic applications. The results of phylogenetic, interpopulation differentiation, and principal coordinates analysis (PCoA) indicate that the Qiang people have extensive connections with ethnic minorities in China, supporting the view that the Qiang people are the oldest group in the entire Sino-Tibetan language family. The Qiang appeared genetically more associated with most ethnic groups in China, especially the Han. The calculation of random matching probability (RMP) was improved by Fst correction of allele frequencies to make RMP more accurate and reasonable. This study can fill in the gaps in the Qiang STR reference database, providing valuable frequency data for forensic applications and evidence for the Qiang's genetic pattern as an important ancestral position in the Sino-Tibetan populations.http://www.sciencedirect.com/science/article/pii/S240584402309031XPopulation geneticsShort tandem repeatX chromosomeAutosomal chromosomeAllele frequencyInterpopulation studies |
| spellingShingle | Zefei Wang Mengyuan Song Qiang Lyu Jun Ying Qian Wu Feng Song Lanrui Jiang Xiaowen Wei Shuangshuang Wang Fei Wang Yuxiang Zhou Xingbo Song Haibo Luo A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China Heliyon Population genetics Short tandem repeat X chromosome Autosomal chromosome Allele frequency Interpopulation studies |
| title | A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China |
| title_full | A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China |
| title_fullStr | A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China |
| title_full_unstemmed | A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China |
| title_short | A forensic population database of autosomal STR and X-STR markers in the Qiang ethnic minority of China |
| title_sort | forensic population database of autosomal str and x str markers in the qiang ethnic minority of china |
| topic | Population genetics Short tandem repeat X chromosome Autosomal chromosome Allele frequency Interpopulation studies |
| url | http://www.sciencedirect.com/science/article/pii/S240584402309031X |
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