Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of α-synuclein are considered main pathological hallmarks of PD, but its etiopathogene...
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Frontiers Media S.A.
2022-04-01
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Series: | Frontiers in Cell and Developmental Biology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.874596/full |
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author | Irene H. Flønes Irene H. Flønes Irene H. Flønes Charalampos Tzoulis Charalampos Tzoulis Charalampos Tzoulis |
author_facet | Irene H. Flønes Irene H. Flønes Irene H. Flønes Charalampos Tzoulis Charalampos Tzoulis Charalampos Tzoulis |
author_sort | Irene H. Flønes |
collection | DOAJ |
description | Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of α-synuclein are considered main pathological hallmarks of PD, but its etiopathogenesis remains largely unknown. Mitochondrial dysfunction, in particular quantitative and/or functional deficiencies of the mitochondrial respiratory chain (MRC), has been associated with the disease. However, after decades of research in this field, the pervasiveness and anatomical extent of MRC dysfunction in PD remain largely unknown. Moreover, it is not known whether the observed MRC defects are pathogenic, compensatory responses, or secondary epiphenomena. In this perspective, we give an overview of current evidence for MRC dysfunction in PD, highlight pertinent knowledge gaps, and propose potential strategies for future research. |
first_indexed | 2024-04-13T15:54:50Z |
format | Article |
id | doaj.art-0ceb55a723c14c01a6431a879bd3f4d4 |
institution | Directory Open Access Journal |
issn | 2296-634X |
language | English |
last_indexed | 2024-04-13T15:54:50Z |
publishDate | 2022-04-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Cell and Developmental Biology |
spelling | doaj.art-0ceb55a723c14c01a6431a879bd3f4d42022-12-22T02:40:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.874596874596Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?Irene H. Flønes0Irene H. Flønes1Irene H. Flønes2Charalampos Tzoulis3Charalampos Tzoulis4Charalampos Tzoulis5Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, NorwayK.G Jebsen Center for Translational Research in Parkinson’s Disease, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayNeuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, NorwayK.G Jebsen Center for Translational Research in Parkinson’s Disease, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayParkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of α-synuclein are considered main pathological hallmarks of PD, but its etiopathogenesis remains largely unknown. Mitochondrial dysfunction, in particular quantitative and/or functional deficiencies of the mitochondrial respiratory chain (MRC), has been associated with the disease. However, after decades of research in this field, the pervasiveness and anatomical extent of MRC dysfunction in PD remain largely unknown. Moreover, it is not known whether the observed MRC defects are pathogenic, compensatory responses, or secondary epiphenomena. In this perspective, we give an overview of current evidence for MRC dysfunction in PD, highlight pertinent knowledge gaps, and propose potential strategies for future research.https://www.frontiersin.org/articles/10.3389/fcell.2022.874596/fullneurodegenerationmitochondrial complex Imitochondriaoxidative phosphorylationParkinson's disease |
spellingShingle | Irene H. Flønes Irene H. Flønes Irene H. Flønes Charalampos Tzoulis Charalampos Tzoulis Charalampos Tzoulis Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease? Frontiers in Cell and Developmental Biology neurodegeneration mitochondrial complex I mitochondria oxidative phosphorylation Parkinson's disease |
title | Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease? |
title_full | Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease? |
title_fullStr | Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease? |
title_full_unstemmed | Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease? |
title_short | Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease? |
title_sort | mitochondrial respiratory chain dysfunction a hallmark pathology of idiopathic parkinson s disease |
topic | neurodegeneration mitochondrial complex I mitochondria oxidative phosphorylation Parkinson's disease |
url | https://www.frontiersin.org/articles/10.3389/fcell.2022.874596/full |
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