Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?

Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of α-synuclein are considered main pathological hallmarks of PD, but its etiopathogene...

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Main Authors: Irene H. Flønes, Charalampos Tzoulis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.874596/full
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author Irene H. Flønes
Irene H. Flønes
Irene H. Flønes
Charalampos Tzoulis
Charalampos Tzoulis
Charalampos Tzoulis
author_facet Irene H. Flønes
Irene H. Flønes
Irene H. Flønes
Charalampos Tzoulis
Charalampos Tzoulis
Charalampos Tzoulis
author_sort Irene H. Flønes
collection DOAJ
description Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of α-synuclein are considered main pathological hallmarks of PD, but its etiopathogenesis remains largely unknown. Mitochondrial dysfunction, in particular quantitative and/or functional deficiencies of the mitochondrial respiratory chain (MRC), has been associated with the disease. However, after decades of research in this field, the pervasiveness and anatomical extent of MRC dysfunction in PD remain largely unknown. Moreover, it is not known whether the observed MRC defects are pathogenic, compensatory responses, or secondary epiphenomena. In this perspective, we give an overview of current evidence for MRC dysfunction in PD, highlight pertinent knowledge gaps, and propose potential strategies for future research.
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spelling doaj.art-0ceb55a723c14c01a6431a879bd3f4d42022-12-22T02:40:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.874596874596Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?Irene H. Flønes0Irene H. Flønes1Irene H. Flønes2Charalampos Tzoulis3Charalampos Tzoulis4Charalampos Tzoulis5Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, NorwayK.G Jebsen Center for Translational Research in Parkinson’s Disease, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayNeuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, NorwayK.G Jebsen Center for Translational Research in Parkinson’s Disease, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayParkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of α-synuclein are considered main pathological hallmarks of PD, but its etiopathogenesis remains largely unknown. Mitochondrial dysfunction, in particular quantitative and/or functional deficiencies of the mitochondrial respiratory chain (MRC), has been associated with the disease. However, after decades of research in this field, the pervasiveness and anatomical extent of MRC dysfunction in PD remain largely unknown. Moreover, it is not known whether the observed MRC defects are pathogenic, compensatory responses, or secondary epiphenomena. In this perspective, we give an overview of current evidence for MRC dysfunction in PD, highlight pertinent knowledge gaps, and propose potential strategies for future research.https://www.frontiersin.org/articles/10.3389/fcell.2022.874596/fullneurodegenerationmitochondrial complex Imitochondriaoxidative phosphorylationParkinson's disease
spellingShingle Irene H. Flønes
Irene H. Flønes
Irene H. Flønes
Charalampos Tzoulis
Charalampos Tzoulis
Charalampos Tzoulis
Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
Frontiers in Cell and Developmental Biology
neurodegeneration
mitochondrial complex I
mitochondria
oxidative phosphorylation
Parkinson's disease
title Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
title_full Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
title_fullStr Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
title_full_unstemmed Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
title_short Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
title_sort mitochondrial respiratory chain dysfunction a hallmark pathology of idiopathic parkinson s disease
topic neurodegeneration
mitochondrial complex I
mitochondria
oxidative phosphorylation
Parkinson's disease
url https://www.frontiersin.org/articles/10.3389/fcell.2022.874596/full
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