Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease
IntroductionPresent study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD].MethodsWe retrospectively included 313 patients (Mean age = 76.40 years, 59 SCD,...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1227325/full |
| _version_ | 1797767507078021120 |
|---|---|
| author | Ye Zhang Yasuko Tatewaki Yasuko Tatewaki Taizen Nakase Taizen Nakase Yingxu Liu Naoki Tomita Naoki Tomita Benjamin Thyreau Haixia Zheng Michiho Muranaka Michiho Muranaka Yumi Takano Yumi Takano Tatsuo Nagasaka Yasuyuki Taki Yasuyuki Taki Yasuyuki Taki |
| author_facet | Ye Zhang Yasuko Tatewaki Yasuko Tatewaki Taizen Nakase Taizen Nakase Yingxu Liu Naoki Tomita Naoki Tomita Benjamin Thyreau Haixia Zheng Michiho Muranaka Michiho Muranaka Yumi Takano Yumi Takano Tatsuo Nagasaka Yasuyuki Taki Yasuyuki Taki Yasuyuki Taki |
| author_sort | Ye Zhang |
| collection | DOAJ |
| description | IntroductionPresent study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD].MethodsWe retrospectively included 313 patients (Mean age = 76.40 years, 59 SCD, 101 MCI, 153 AD) in a cross-sectional analysis and 91 patients (Mean age = 75.83 years, 12 SCD, 43 MCI, 36 AD) in a longitudinal analysis. Multivariable linear regression was conducted to investigate the relationship between hs-CRP concentration and brain structural alterations, and cognitive function, respectively.ResultsHs-CRP was positively associated with gray matter volume in the left fusiform (β = 0.16, pFDR = 0.023) and the left parahippocampal gyrus (β = 0.16, pFDR = 0.029). Post hoc analysis revealed that these associations were mainly driven by patients with MCI and AD. The interaction of diagnosis and CRP was significantly associated with annual cognitive changes (β = 0.43, p = 0.008). Among these patients with AD, lower baseline CRP was correlated with greater future cognitive decline (r = −0.41, p = 0.013).ConclusionOur study suggests that increased hs-CRP level may exert protective effect on brain structure alterations and future cognitive changes among patients already with cognitive impairment. |
| first_indexed | 2024-03-12T20:40:47Z |
| format | Article |
| id | doaj.art-0cebcfa741044882be90239375ccda46 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T20:40:47Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-0cebcfa741044882be90239375ccda462023-08-01T10:46:04ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-08-011510.3389/fnagi.2023.12273251227325Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s diseaseYe Zhang0Yasuko Tatewaki1Yasuko Tatewaki2Taizen Nakase3Taizen Nakase4Yingxu Liu5Naoki Tomita6Naoki Tomita7Benjamin Thyreau8Haixia Zheng9Michiho Muranaka10Michiho Muranaka11Yumi Takano12Yumi Takano13Tatsuo Nagasaka14Yasuyuki Taki15Yasuyuki Taki16Yasuyuki Taki17Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanSmart-Aging Research Center, Tohoku University, Sendai, JapanLaureate Institute for Brain Research, Tulsa, OK, United StatesDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDivision of Radiology, Tohoku University Hospital, Sendai, JapanDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanSmart-Aging Research Center, Tohoku University, Sendai, JapanIntroductionPresent study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD].MethodsWe retrospectively included 313 patients (Mean age = 76.40 years, 59 SCD, 101 MCI, 153 AD) in a cross-sectional analysis and 91 patients (Mean age = 75.83 years, 12 SCD, 43 MCI, 36 AD) in a longitudinal analysis. Multivariable linear regression was conducted to investigate the relationship between hs-CRP concentration and brain structural alterations, and cognitive function, respectively.ResultsHs-CRP was positively associated with gray matter volume in the left fusiform (β = 0.16, pFDR = 0.023) and the left parahippocampal gyrus (β = 0.16, pFDR = 0.029). Post hoc analysis revealed that these associations were mainly driven by patients with MCI and AD. The interaction of diagnosis and CRP was significantly associated with annual cognitive changes (β = 0.43, p = 0.008). Among these patients with AD, lower baseline CRP was correlated with greater future cognitive decline (r = −0.41, p = 0.013).ConclusionOur study suggests that increased hs-CRP level may exert protective effect on brain structure alterations and future cognitive changes among patients already with cognitive impairment.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1227325/fullgray matter volumesystemic inflammationC-reactive proteinFreeSurfersubjective cognitive declineAlzheimer’s disease |
| spellingShingle | Ye Zhang Yasuko Tatewaki Yasuko Tatewaki Taizen Nakase Taizen Nakase Yingxu Liu Naoki Tomita Naoki Tomita Benjamin Thyreau Haixia Zheng Michiho Muranaka Michiho Muranaka Yumi Takano Yumi Takano Tatsuo Nagasaka Yasuyuki Taki Yasuyuki Taki Yasuyuki Taki Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease Frontiers in Aging Neuroscience gray matter volume systemic inflammation C-reactive protein FreeSurfer subjective cognitive decline Alzheimer’s disease |
| title | Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease |
| title_full | Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease |
| title_fullStr | Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease |
| title_full_unstemmed | Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease |
| title_short | Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease |
| title_sort | impact of hs crp concentration on brain structure alterations and cognitive trajectory in alzheimer s disease |
| topic | gray matter volume systemic inflammation C-reactive protein FreeSurfer subjective cognitive decline Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1227325/full |
| work_keys_str_mv | AT yezhang impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yasukotatewaki impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yasukotatewaki impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT taizennakase impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT taizennakase impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yingxuliu impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT naokitomita impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT naokitomita impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT benjaminthyreau impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT haixiazheng impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT michihomuranaka impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT michihomuranaka impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yumitakano impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yumitakano impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT tatsuonagasaka impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yasuyukitaki impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yasuyukitaki impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease AT yasuyukitaki impactofhscrpconcentrationonbrainstructurealterationsandcognitivetrajectoryinalzheimersdisease |