Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases
Bone metabolic diseases have been tormented and are plaguing people worldwide due to the lack of effective and thorough medical interventions and the poor understanding of their pathogenesis. Non-coding RNAs (ncRNAs) are heterogeneous transcripts that cannot encode the proteins but can affect the ex...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1178310/full |
| _version_ | 1797401394176589824 |
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| author | Binghan Yan Zhichao Li Hui Su Haipeng Xue Daodi Qiu Zhanwang Xu Guoqing Tan |
| author_facet | Binghan Yan Zhichao Li Hui Su Haipeng Xue Daodi Qiu Zhanwang Xu Guoqing Tan |
| author_sort | Binghan Yan |
| collection | DOAJ |
| description | Bone metabolic diseases have been tormented and are plaguing people worldwide due to the lack of effective and thorough medical interventions and the poor understanding of their pathogenesis. Non-coding RNAs (ncRNAs) are heterogeneous transcripts that cannot encode the proteins but can affect the expressions of other genes. Autophagy is a fundamental mechanism for keeping cell viability, recycling cellular contents through the lysosomal pathway, and maintaining the homeostasis of the intracellular environment. There is growing evidence that ncRNAs, autophagy, and crosstalk between ncRNAs and autophagy play complex roles in progression of metabolic bone disease. This review investigated the complex mechanisms by which ncRNAs, mainly micro RNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate autophagic pathway to assist in treating bone metabolism disorders. It aimed at identifying the autophagy role in bone metabolism disorders and understanding the role, potential, and challenges of crosstalk between ncRNAs and autophagy for bone metabolism disorders treatment. |
| first_indexed | 2024-03-09T02:09:23Z |
| format | Article |
| id | doaj.art-0cec861f56924bf1ae292eba7a18940f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T02:09:23Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0cec861f56924bf1ae292eba7a18940f2023-12-07T14:21:23ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.11783101178310Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseasesBinghan Yan0Zhichao Li1Hui Su2Haipeng Xue3Daodi Qiu4Zhanwang Xu5Guoqing Tan6College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaBone metabolic diseases have been tormented and are plaguing people worldwide due to the lack of effective and thorough medical interventions and the poor understanding of their pathogenesis. Non-coding RNAs (ncRNAs) are heterogeneous transcripts that cannot encode the proteins but can affect the expressions of other genes. Autophagy is a fundamental mechanism for keeping cell viability, recycling cellular contents through the lysosomal pathway, and maintaining the homeostasis of the intracellular environment. There is growing evidence that ncRNAs, autophagy, and crosstalk between ncRNAs and autophagy play complex roles in progression of metabolic bone disease. This review investigated the complex mechanisms by which ncRNAs, mainly micro RNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate autophagic pathway to assist in treating bone metabolism disorders. It aimed at identifying the autophagy role in bone metabolism disorders and understanding the role, potential, and challenges of crosstalk between ncRNAs and autophagy for bone metabolism disorders treatment.https://www.frontiersin.org/articles/10.3389/fphar.2023.1178310/fullautophagyncRNAsbone metabolismosteoporosisosteoarthritisrheumatoid arthritis |
| spellingShingle | Binghan Yan Zhichao Li Hui Su Haipeng Xue Daodi Qiu Zhanwang Xu Guoqing Tan Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases Frontiers in Pharmacology autophagy ncRNAs bone metabolism osteoporosis osteoarthritis rheumatoid arthritis |
| title | Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases |
| title_full | Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases |
| title_fullStr | Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases |
| title_full_unstemmed | Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases |
| title_short | Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases |
| title_sort | regulatory mechanisms of autophagy related ncrnas in bone metabolic diseases |
| topic | autophagy ncRNAs bone metabolism osteoporosis osteoarthritis rheumatoid arthritis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1178310/full |
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