Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
Altered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteration, rather than epigenetic alterations.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00639-9 |
| _version_ | 1828976736653541376 |
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| author | Alex Martin-Trujillo Enrique Vidal Ana Monteagudo-Sánchez Marta Sanchez-Delgado Sebastian Moran Jose Ramon Hernandez Mora Holger Heyn Miriam Guitart Manel Esteller David Monk |
| author_facet | Alex Martin-Trujillo Enrique Vidal Ana Monteagudo-Sánchez Marta Sanchez-Delgado Sebastian Moran Jose Ramon Hernandez Mora Holger Heyn Miriam Guitart Manel Esteller David Monk |
| author_sort | Alex Martin-Trujillo |
| collection | DOAJ |
| description | Altered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteration, rather than epigenetic alterations. |
| first_indexed | 2024-12-14T14:44:33Z |
| format | Article |
| id | doaj.art-0ced9395b01e4ea4b12aeea8da2c0e0e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:44:33Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0ced9395b01e4ea4b12aeea8da2c0e0e2022-12-21T22:57:18ZengNature PortfolioNature Communications2041-17232017-09-018111210.1038/s41467-017-00639-9Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumorsAlex Martin-Trujillo0Enrique Vidal1Ana Monteagudo-Sánchez2Marta Sanchez-Delgado3Sebastian Moran4Jose Ramon Hernandez Mora5Holger Heyn6Miriam Guitart7Manel Esteller8David Monk9Imprinting and Cancer group, Cancer Epigenetic and Biology Program (PEBC), Institut d’Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L’Hospitalet de LlobregatCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyImprinting and Cancer group, Cancer Epigenetic and Biology Program (PEBC), Institut d’Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L’Hospitalet de LlobregatImprinting and Cancer group, Cancer Epigenetic and Biology Program (PEBC), Institut d’Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L’Hospitalet de LlobregatCancer Epigenetics group, Cancer Epigenetic and Biology Program (PEBC), Institut d’Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L’Hospitalet de LlobregatImprinting and Cancer group, Cancer Epigenetic and Biology Program (PEBC), Institut d’Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L’Hospitalet de LlobregatUniversitat Pompeu Fabra (UPF), Barcelona, Spain Universitat Pompeu Fabra (UPF)Genetics Laboratory, UDIAT- Diagnostic Centre, Corporació Sanitària Parc TaulíCancer Epigenetics group, Cancer Epigenetic and Biology Program (PEBC), Institut d’Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L’Hospitalet de LlobregatImprinting and Cancer group, Cancer Epigenetic and Biology Program (PEBC), Institut d’Investigació Biomedica de Bellvitge (IDIBELL), Avinguda Granvia, L’Hospitalet de LlobregatAltered genomic imprinting is frequently reported in cancer. Here, the authors analyze copy number and methylation in cancer cell lines and primary tumors to show that imprinted methylation profiles represent the accumulation of copy number alteration, rather than epigenetic alterations.https://doi.org/10.1038/s41467-017-00639-9 |
| spellingShingle | Alex Martin-Trujillo Enrique Vidal Ana Monteagudo-Sánchez Marta Sanchez-Delgado Sebastian Moran Jose Ramon Hernandez Mora Holger Heyn Miriam Guitart Manel Esteller David Monk Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors Nature Communications |
| title | Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors |
| title_full | Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors |
| title_fullStr | Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors |
| title_full_unstemmed | Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors |
| title_short | Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors |
| title_sort | copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors |
| url | https://doi.org/10.1038/s41467-017-00639-9 |
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