Research Advance of Hypoxia-regulated miR-210 in Cancer
The uncontrolled proliferation of tumor cells and the relative deficiency of the internal neovascularization network lead to insufficient oxygen supply. Hypoxia, an important feature of tumor microenvironment, can active the expression of hypoxia-inducible factors(HIFs) and induce the change of a nu...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2018-07-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1457.htm |
| _version_ | 1819106604458442752 |
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| author | CAO Zheng FENG Lin FENG Xiaoli |
| author_facet | CAO Zheng FENG Lin FENG Xiaoli |
| author_sort | CAO Zheng |
| collection | DOAJ |
| description | The uncontrolled proliferation of tumor cells and the relative deficiency of the internal neovascularization network lead to insufficient oxygen supply. Hypoxia, an important feature of tumor microenvironment, can active the expression of hypoxia-inducible factors(HIFs) and induce the change of a number of miRNAs (microRNAs, miRs) content. miRNA are small, noncoding RNA, regulating gene expression mainly at post-transcriptional level. miR-210 have an important role in the occurrence and development of tumors as the most principal hypoxia-regulated-miRNAs, participating in cell activities such as mitochondrial metabolism, angiogenesis, cell cycle regulation, DNA repair and so on; miR-210 is over-expressed in most tumor tissues and plasma, and correlated with poor prognosis, therefore, miR-210 can be used for tumor screening, diagnosing and predicting the prognosis of patients. With the further study of downstream target gene of miR-210, the target therapy aiming at miR-210-mediated signal pathway provides a broader prospect for the treatment of malignant tumor. |
| first_indexed | 2024-12-22T02:40:47Z |
| format | Article |
| id | doaj.art-0cf121e98b184444bb3629348ef1dc76 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-22T02:40:47Z |
| publishDate | 2018-07-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-0cf121e98b184444bb3629348ef1dc762022-12-21T18:41:38ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782018-07-0145750050410.3971/j.issn.1000-8578.2018.17.14578578.2018.17.1457Research Advance of Hypoxia-regulated miR-210 in CancerCAO Zheng0FENG Lin1FENG Xiaoli2Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, ChinaThe uncontrolled proliferation of tumor cells and the relative deficiency of the internal neovascularization network lead to insufficient oxygen supply. Hypoxia, an important feature of tumor microenvironment, can active the expression of hypoxia-inducible factors(HIFs) and induce the change of a number of miRNAs (microRNAs, miRs) content. miRNA are small, noncoding RNA, regulating gene expression mainly at post-transcriptional level. miR-210 have an important role in the occurrence and development of tumors as the most principal hypoxia-regulated-miRNAs, participating in cell activities such as mitochondrial metabolism, angiogenesis, cell cycle regulation, DNA repair and so on; miR-210 is over-expressed in most tumor tissues and plasma, and correlated with poor prognosis, therefore, miR-210 can be used for tumor screening, diagnosing and predicting the prognosis of patients. With the further study of downstream target gene of miR-210, the target therapy aiming at miR-210-mediated signal pathway provides a broader prospect for the treatment of malignant tumor.http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1457.htmcancerhypoxiahif-1mir-210 |
| spellingShingle | CAO Zheng FENG Lin FENG Xiaoli Research Advance of Hypoxia-regulated miR-210 in Cancer Zhongliu Fangzhi Yanjiu cancer hypoxia hif-1 mir-210 |
| title | Research Advance of Hypoxia-regulated miR-210 in Cancer |
| title_full | Research Advance of Hypoxia-regulated miR-210 in Cancer |
| title_fullStr | Research Advance of Hypoxia-regulated miR-210 in Cancer |
| title_full_unstemmed | Research Advance of Hypoxia-regulated miR-210 in Cancer |
| title_short | Research Advance of Hypoxia-regulated miR-210 in Cancer |
| title_sort | research advance of hypoxia regulated mir 210 in cancer |
| topic | cancer hypoxia hif-1 mir-210 |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2018.17.1457.htm |
| work_keys_str_mv | AT caozheng researchadvanceofhypoxiaregulatedmir210incancer AT fenglin researchadvanceofhypoxiaregulatedmir210incancer AT fengxiaoli researchadvanceofhypoxiaregulatedmir210incancer |