Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08405-9 |
| _version_ | 1818992734475649024 |
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| author | Jessica Gräb Isabelle Suárez Edeltraud van Gumpel Sandra Winter Fynn Schreiber Anna Esser Christoph Hölscher Melanie Fritsch Marc Herb Michael Schramm Laurens Wachsmuth Christian Pallasch Manolis Pasparakis Hamid Kashkar Jan Rybniker |
| author_facet | Jessica Gräb Isabelle Suárez Edeltraud van Gumpel Sandra Winter Fynn Schreiber Anna Esser Christoph Hölscher Melanie Fritsch Marc Herb Michael Schramm Laurens Wachsmuth Christian Pallasch Manolis Pasparakis Hamid Kashkar Jan Rybniker |
| author_sort | Jessica Gräb |
| collection | DOAJ |
| description | Corticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK. |
| first_indexed | 2024-12-20T20:30:52Z |
| format | Article |
| id | doaj.art-0cf1b079bcdc4e2c9b9dc63c3752ff0e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:30:52Z |
| publishDate | 2019-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0cf1b079bcdc4e2c9b9dc63c3752ff0e2022-12-21T19:27:21ZengNature PortfolioNature Communications2041-17232019-02-0110111410.1038/s41467-019-08405-9Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transitionJessica Gräb0Isabelle Suárez1Edeltraud van Gumpel2Sandra Winter3Fynn Schreiber4Anna Esser5Christoph Hölscher6Melanie Fritsch7Marc Herb8Michael Schramm9Laurens Wachsmuth10Christian Pallasch11Manolis Pasparakis12Hamid Kashkar13Jan Rybniker14Department I of Internal Medicine, University of CologneDepartment I of Internal Medicine, University of CologneDepartment I of Internal Medicine, University of CologneDepartment I of Internal Medicine, University of CologneDepartment I of Internal Medicine, University of CologneDepartment I of Internal Medicine, University of CologneGerman Center for Infection Research (DZIF), Partner Site Bonn-CologneCenter for Molecular Medicine Cologne (CMMC), University of CologneExcellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of CologneExcellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of CologneInstitute for Genetics, University of CologneDepartment I of Internal Medicine, University of CologneCenter for Molecular Medicine Cologne (CMMC), University of CologneCenter for Molecular Medicine Cologne (CMMC), University of CologneDepartment I of Internal Medicine, University of CologneCorticosteroids are host-directed drugs that enhance survival of tuberculosis patients through unclear mechanisms. Here, Gräb et al. show that corticosteroids inhibit necrotic death of cells infected with Mycobacterium tuberculosis by facilitating MKP-1-dependent dephosphorylation of p38 MAPK.https://doi.org/10.1038/s41467-019-08405-9 |
| spellingShingle | Jessica Gräb Isabelle Suárez Edeltraud van Gumpel Sandra Winter Fynn Schreiber Anna Esser Christoph Hölscher Melanie Fritsch Marc Herb Michael Schramm Laurens Wachsmuth Christian Pallasch Manolis Pasparakis Hamid Kashkar Jan Rybniker Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition Nature Communications |
| title | Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition |
| title_full | Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition |
| title_fullStr | Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition |
| title_full_unstemmed | Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition |
| title_short | Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition |
| title_sort | corticosteroids inhibit mycobacterium tuberculosis induced necrotic host cell death by abrogating mitochondrial membrane permeability transition |
| url | https://doi.org/10.1038/s41467-019-08405-9 |
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