Physiological and Aberrant γ-Globin Transcription During Development

Physiological and Aberrant γ-Globin Transcription During Development

The expression of the fetal Gγ- and Aγ-globin genes in normal development is confined to the fetal period, where two γ-globin chains assemble with two α-globin chains to form α2γ2 tetramers (HbF). HbF sustains oxygen delivery to tissues until birth, when β-globin replaces γ-globin, leading to the fo...

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Bibliographic Details
Main Authors:	Gloria Barbarani, Agata Labedz, Sarah Stucchi, Alessia Abbiati, Antonella E. Ronchi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	globin genes transcription factors hereditary persistence of fetal hemoglobin juvenile myelomonocytic leukemia erythropoiesis
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.640060/full

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