Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical Applications
Chrysin (CH) and Caffeic acid (CA) loaded polymer films are designed as antibacterial polymer films with the advantages of a sustained release. Polymer blend film was prepared by solution casting method of (polyvinyl alcohol) (PVA) blend with Poly (vinylpyrrolidone) PVP and glycerine (GL) as plastic...
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| Format: | Article |
| Language: | English |
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Unviversity of Technology- Iraq
2016-06-01
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| Series: | Engineering and Technology Journal |
| Subjects: | |
| Online Access: | https://etj.uotechnology.edu.iq/article_126838_f82735467a6c4019eb37cd46b6fcfafd.pdf |
| _version_ | 1827358716722151424 |
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| author | Shemaa Abdul Sattar Saood Ghassan M. Sulaiman |
| author_facet | Shemaa Abdul Sattar Saood Ghassan M. Sulaiman |
| author_sort | Shemaa Abdul Sattar Saood |
| collection | DOAJ |
| description | Chrysin (CH) and Caffeic acid (CA) loaded polymer films are designed as antibacterial polymer films with the advantages of a sustained release. Polymer blend film was prepared by solution casting method of (polyvinyl alcohol) (PVA) blend with Poly (vinylpyrrolidone) PVP and glycerine (GL) as plasticizer in addition to glutaraldehydeas cross linker. The surface characteristics of film were assessed by scanning electron microscopy .Furthermore, the swelling behavior was followed in DSMO and PBS. PVA/PVP films were loaded with 1, 10 and 50% for either CH or CA. Release kinetics was followed for 24 hr in PBS at 37◦C. The cumulative amount released from the polymeric PVA/PVP film loaded with 1, 10 and 50% of CH over the entire period 24 h was found to be 0.087, 0.127 and 0.146 gm, respectively .While the cumulative amount of CA released in same condition was found to be 0.875, 0.766 and 1.13 gm respectively. Antibacterial activity for both CH and CA released from the film was tested against two type of bacterial strains Staphylococcus aureuas and Escherichia coli. |
| first_indexed | 2024-03-08T06:15:08Z |
| format | Article |
| id | doaj.art-0cf6dd31ab9e420b835f453b8f99bb4b |
| institution | Directory Open Access Journal |
| issn | 1681-6900 2412-0758 |
| language | English |
| last_indexed | 2024-03-08T06:15:08Z |
| publishDate | 2016-06-01 |
| publisher | Unviversity of Technology- Iraq |
| record_format | Article |
| series | Engineering and Technology Journal |
| spelling | doaj.art-0cf6dd31ab9e420b835f453b8f99bb4b2024-02-04T17:27:40ZengUnviversity of Technology- IraqEngineering and Technology Journal1681-69002412-07582016-06-01346B84285110.30684/etj.34.6B.13126838Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical ApplicationsShemaa Abdul Sattar SaoodGhassan M. SulaimanChrysin (CH) and Caffeic acid (CA) loaded polymer films are designed as antibacterial polymer films with the advantages of a sustained release. Polymer blend film was prepared by solution casting method of (polyvinyl alcohol) (PVA) blend with Poly (vinylpyrrolidone) PVP and glycerine (GL) as plasticizer in addition to glutaraldehydeas cross linker. The surface characteristics of film were assessed by scanning electron microscopy .Furthermore, the swelling behavior was followed in DSMO and PBS. PVA/PVP films were loaded with 1, 10 and 50% for either CH or CA. Release kinetics was followed for 24 hr in PBS at 37◦C. The cumulative amount released from the polymeric PVA/PVP film loaded with 1, 10 and 50% of CH over the entire period 24 h was found to be 0.087, 0.127 and 0.146 gm, respectively .While the cumulative amount of CA released in same condition was found to be 0.875, 0.766 and 1.13 gm respectively. Antibacterial activity for both CH and CA released from the film was tested against two type of bacterial strains Staphylococcus aureuas and Escherichia coli.https://etj.uotechnology.edu.iq/article_126838_f82735467a6c4019eb37cd46b6fcfafd.pdfpolymer filmchrysincaffeic acidpolymer blendsreleasing |
| spellingShingle | Shemaa Abdul Sattar Saood Ghassan M. Sulaiman Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical Applications Engineering and Technology Journal polymer film chrysin caffeic acid polymer blends releasing |
| title | Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical Applications |
| title_full | Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical Applications |
| title_fullStr | Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical Applications |
| title_full_unstemmed | Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical Applications |
| title_short | Synthesis of Biocompatible Polymer Blend for Drug Delivery in Biomedical Applications |
| title_sort | synthesis of biocompatible polymer blend for drug delivery in biomedical applications |
| topic | polymer film chrysin caffeic acid polymer blends releasing |
| url | https://etj.uotechnology.edu.iq/article_126838_f82735467a6c4019eb37cd46b6fcfafd.pdf |
| work_keys_str_mv | AT shemaaabdulsattarsaood synthesisofbiocompatiblepolymerblendfordrugdeliveryinbiomedicalapplications AT ghassanmsulaiman synthesisofbiocompatiblepolymerblendfordrugdeliveryinbiomedicalapplications |