Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks.
Long-term memory formation involves the reorganization of brain circuits, termed system consolidation. Whether and how a prior fear experience influences system consolidation of new memories is poorly understood. In rats, we found that prior auditory fear learning allows the secondary auditory corte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-09-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3001789 |
| _version_ | 1811246348876382208 |
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| author | Giulia Concina Annamaria Renna Luisella Milano Benedetto Sacchetti |
| author_facet | Giulia Concina Annamaria Renna Luisella Milano Benedetto Sacchetti |
| author_sort | Giulia Concina |
| collection | DOAJ |
| description | Long-term memory formation involves the reorganization of brain circuits, termed system consolidation. Whether and how a prior fear experience influences system consolidation of new memories is poorly understood. In rats, we found that prior auditory fear learning allows the secondary auditory cortex to immediately encode new auditory memories, with these new memories purely requiring the activation of cellular mechanisms of synaptic consolidation within secondary auditory cortex. Similar results were obtained in the anterior cingulate cortex for contextual fear memories. Moreover, prior learning enabled connections from these cortices to the basolateral amygdala (BLA) to support recent memory retention. We propose that the reorganization of circuits that characterizes system consolidation occurs only in the first instance that an event is learned, subsequently allowing the immediate assimilation of new analogous events in final storage sites. |
| first_indexed | 2024-04-12T14:52:12Z |
| format | Article |
| id | doaj.art-0cf98420c2e34c5fb327462ab4995641 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-04-12T14:52:12Z |
| publishDate | 2022-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-0cf98420c2e34c5fb327462ab49956412022-12-22T03:28:23ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852022-09-01209e300178910.1371/journal.pbio.3001789Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks.Giulia ConcinaAnnamaria RennaLuisella MilanoBenedetto SacchettiLong-term memory formation involves the reorganization of brain circuits, termed system consolidation. Whether and how a prior fear experience influences system consolidation of new memories is poorly understood. In rats, we found that prior auditory fear learning allows the secondary auditory cortex to immediately encode new auditory memories, with these new memories purely requiring the activation of cellular mechanisms of synaptic consolidation within secondary auditory cortex. Similar results were obtained in the anterior cingulate cortex for contextual fear memories. Moreover, prior learning enabled connections from these cortices to the basolateral amygdala (BLA) to support recent memory retention. We propose that the reorganization of circuits that characterizes system consolidation occurs only in the first instance that an event is learned, subsequently allowing the immediate assimilation of new analogous events in final storage sites.https://doi.org/10.1371/journal.pbio.3001789 |
| spellingShingle | Giulia Concina Annamaria Renna Luisella Milano Benedetto Sacchetti Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks. PLoS Biology |
| title | Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks. |
| title_full | Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks. |
| title_fullStr | Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks. |
| title_full_unstemmed | Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks. |
| title_short | Prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks. |
| title_sort | prior fear learning enables the rapid assimilation of new fear memories directly into cortical networks |
| url | https://doi.org/10.1371/journal.pbio.3001789 |
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