Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf
Hepatitis B virus (HBV) has been classified into 8 genotypes (A-H). Genotypes A, D and F have been identified in some South American countries, but in Venezuela studies have been more restricted to aboriginal communities where genotype F is predominant. The aim of the present study was to identify t...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-04-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119316576 |
| _version_ | 1818899699104481280 |
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| author | Irma V. Machado María del Pilar Fortes Berta Vargas-Lovelle Aleidy C. Trómpiz Danerys A. López Roberto V. León Merita Senior Lucy Dagher Carmen E. López Elena Pestaña Román Bacalao Miguel E. Garassini |
| author_facet | Irma V. Machado María del Pilar Fortes Berta Vargas-Lovelle Aleidy C. Trómpiz Danerys A. López Roberto V. León Merita Senior Lucy Dagher Carmen E. López Elena Pestaña Román Bacalao Miguel E. Garassini |
| author_sort | Irma V. Machado |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) has been classified into 8 genotypes (A-H). Genotypes A, D and F have been identified in some South American countries, but in Venezuela studies have been more restricted to aboriginal communities where genotype F is predominant. The aim of the present study was to identify the prevalence of HBV genotypes among native HBsAg carriers in Venezuelan urban areas. In addition, we correlated the predominant HBV genotype with epidemiological, serological and virological features of the infection. Non-Venezuelan migrant patients were excluded from this study. Serum samples from 90 patients (21 children and 69 adults) with chronic hepatitis B (CHB) were analyzed. Seventy-four patients had CHB e-antigen positive and 16 CHB e-antigen negative. HBV DNA serum levels of the whole group ranged from 4.1 to 8.8 log1H IU/mL. Patients with CHB e-antigen positive showed significantly higher viral loads (P = 0.0001) than the group with CHB e-antigen negative. Eighty-eight patients (97.8%) exhibited HBV genotype F while two non-related patients (2.2%) were infected with A + F genotypes. Genotype F is the main circulating HBV strain among HBsAg carriers from Venezuelan urban areas. This genotype is associated mostly with CHB e-antigen positive and high rate of transmission. Progression to cirrhosis and hepatocellular carcinoma could be major clinical events of this patient population independently of age at acquisition or transmission route. |
| first_indexed | 2024-12-19T19:52:07Z |
| format | Article |
| id | doaj.art-0cf988027044493492b9ed2dd74b4f20 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-19T19:52:07Z |
| publishDate | 2010-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-0cf988027044493492b9ed2dd74b4f202022-12-21T20:07:57ZengElsevierAnnals of Hepatology1665-26812010-04-0192172176Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_AbstractspdfIrma V. Machado0María del Pilar Fortes1Berta Vargas-Lovelle2Aleidy C. Trómpiz3Danerys A. López4Roberto V. León5Merita Senior6Lucy Dagher7Carmen E. López8Elena Pestaña9Román Bacalao10Miguel E. Garassini11Laboratorio Clínico Especializado Intediag-HV (Integración Diagnóstica en Hepatitis Viral), Caracas, Venezuela; Correspondence and reprint request:Laboratorio Clínico Especializado Intediag-HV (Integración Diagnóstica en Hepatitis Viral), Caracas, VenezuelaLaboratorio Clínico Especializado Intediag-HV (Integración Diagnóstica en Hepatitis Viral), Caracas, VenezuelaLaboratorio Clínico Especializado Intediag-HV (Integración Diagnóstica en Hepatitis Viral), Caracas, VenezuelaLaboratorio Clínico Especializado Intediag-HV (Integración Diagnóstica en Hepatitis Viral), Caracas, VenezuelaHospital General “Domingo Luciani” and Instituto Médico La Floresta, CaracasHospital de Clínicas CaracasCentro Médico Docente La Trinidad, CaracasHospital de Niños “J.M. de Los Ríos”, CaracasFundación Zuliana del Hígado, Maracaibo, Estado Zulia and Policlínica Metropolitana, CaracasCentro Médico de CaracasCentro Médico Docente La Trinidad, CaracasHepatitis B virus (HBV) has been classified into 8 genotypes (A-H). Genotypes A, D and F have been identified in some South American countries, but in Venezuela studies have been more restricted to aboriginal communities where genotype F is predominant. The aim of the present study was to identify the prevalence of HBV genotypes among native HBsAg carriers in Venezuelan urban areas. In addition, we correlated the predominant HBV genotype with epidemiological, serological and virological features of the infection. Non-Venezuelan migrant patients were excluded from this study. Serum samples from 90 patients (21 children and 69 adults) with chronic hepatitis B (CHB) were analyzed. Seventy-four patients had CHB e-antigen positive and 16 CHB e-antigen negative. HBV DNA serum levels of the whole group ranged from 4.1 to 8.8 log1H IU/mL. Patients with CHB e-antigen positive showed significantly higher viral loads (P = 0.0001) than the group with CHB e-antigen negative. Eighty-eight patients (97.8%) exhibited HBV genotype F while two non-related patients (2.2%) were infected with A + F genotypes. Genotype F is the main circulating HBV strain among HBsAg carriers from Venezuelan urban areas. This genotype is associated mostly with CHB e-antigen positive and high rate of transmission. Progression to cirrhosis and hepatocellular carcinoma could be major clinical events of this patient population independently of age at acquisition or transmission route.http://www.sciencedirect.com/science/article/pii/S1665268119316576Genotype FChronic hepatitis Be-entigenAnti-eHB antibodiesUrban HBV carrier |
| spellingShingle | Irma V. Machado María del Pilar Fortes Berta Vargas-Lovelle Aleidy C. Trómpiz Danerys A. López Roberto V. León Merita Senior Lucy Dagher Carmen E. López Elena Pestaña Román Bacalao Miguel E. Garassini Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf Annals of Hepatology Genotype F Chronic hepatitis B e-entigen Anti-eHB antibodies Urban HBV carrier |
| title | Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf |
| title_full | Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf |
| title_fullStr | Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf |
| title_full_unstemmed | Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf |
| title_short | Genotype f prevails in Venezuelan urban patients with chronic hepatitis B(a)(a)This project was supported, in part, by an award to Intediag-HV granted by Fondo Pro-Salud 2007, Cámara Venezolana de Fabricantes de Cerveza (CAVEFACE), Venezuela. A preliminary report of this work was presented in an abstract form at the 13th International Symposium on Viral Hepatitis and Liver Disease, March, 2009, Washington, USA. www.ishld2009.org/pdf/ISVHLD_Poster_Presentation_Abstractspdf |
| title_sort | genotype f prevails in venezuelan urban patients with chronic hepatitis b a a this project was supported in part by an award to intediag hv granted by fondo pro salud 2007 camara venezolana de fabricantes de cerveza caveface venezuela a preliminary report of this work was presented in an abstract form at the 13th international symposium on viral hepatitis and liver disease march 2009 washington usa www ishld2009 org pdf isvhld poster presentation abstractspdf |
| topic | Genotype F Chronic hepatitis B e-entigen Anti-eHB antibodies Urban HBV carrier |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119316576 |
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