A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?
Thyroid hormones play a crucial role in regulating normal development, growth, and metabolic function. However, the controversy surrounding seasonal changes in free triiodothyronine (FT3) levels remains unresolved. Therefore, the aim of this study was to conduct a systematic review and meta-analysis...
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14052 |
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| author | Alena A. Nikanorova Nikolay A. Barashkov Vera G. Pshennikova Fedor M. Teryutin Sergey S. Nakhodkin Aisen V. Solovyev Georgii P. Romanov Tatiana E. Burtseva Sardana A. Fedorova |
| author_facet | Alena A. Nikanorova Nikolay A. Barashkov Vera G. Pshennikova Fedor M. Teryutin Sergey S. Nakhodkin Aisen V. Solovyev Georgii P. Romanov Tatiana E. Burtseva Sardana A. Fedorova |
| author_sort | Alena A. Nikanorova |
| collection | DOAJ |
| description | Thyroid hormones play a crucial role in regulating normal development, growth, and metabolic function. However, the controversy surrounding seasonal changes in free triiodothyronine (FT3) levels remains unresolved. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of variations in FT3 levels in relation to seasonal air temperatures in the context of current knowledge about its role in nonshivering thermogenesis. Ten eligible articles with a total of 336,755 participants were included in the meta-analysis. The studies were categorized into two groups based on the air temperature: “Cold winter”, where the winter temperature fell below 0 °C, and “Warm winter”, where the winter temperature was above 0 °C. The analysis revealed that in cold regions, FT3 levels decreased in winter compared to summer (I<sup>2</sup> = 57%, <i>p</i> < 0.001), whereas in warm regions, FT3 levels increased during winter (I<sup>2</sup> = 28%, <i>p</i> < 0.001). These findings suggest that seasonal variations in FT3 levels are likely to be influenced by the winter temperature. Considering the important role of the FT3 in the nonshivering thermogenesis process, we assume that this observed pattern is probably related to the differences in use of thyroid hormones in the brown adipose tissue during adaptive thermogenesis, which may depend on intensity of cold exposure. |
| first_indexed | 2024-03-10T22:39:55Z |
| format | Article |
| id | doaj.art-0cf9fd0fce0a440d8e9d12b33a2d2a27 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:55Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0cf9fd0fce0a440d8e9d12b33a2d2a272023-11-19T11:07:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181405210.3390/ijms241814052A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?Alena A. Nikanorova0Nikolay A. Barashkov1Vera G. Pshennikova2Fedor M. Teryutin3Sergey S. Nakhodkin4Aisen V. Solovyev5Georgii P. Romanov6Tatiana E. Burtseva7Sardana A. Fedorova8Yakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, RussiaYakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, RussiaYakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, RussiaYakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, RussiaM.K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677013 Yakutsk, RussiaM.K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677013 Yakutsk, RussiaM.K. Ammosov North-Eastern Federal University, Kulakovskogo 46, 677013 Yakutsk, RussiaYakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, RussiaYakut Science Centre of Complex Medical Problems, Yaroslavskogo 6/3, 677000 Yakutsk, RussiaThyroid hormones play a crucial role in regulating normal development, growth, and metabolic function. However, the controversy surrounding seasonal changes in free triiodothyronine (FT3) levels remains unresolved. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of variations in FT3 levels in relation to seasonal air temperatures in the context of current knowledge about its role in nonshivering thermogenesis. Ten eligible articles with a total of 336,755 participants were included in the meta-analysis. The studies were categorized into two groups based on the air temperature: “Cold winter”, where the winter temperature fell below 0 °C, and “Warm winter”, where the winter temperature was above 0 °C. The analysis revealed that in cold regions, FT3 levels decreased in winter compared to summer (I<sup>2</sup> = 57%, <i>p</i> < 0.001), whereas in warm regions, FT3 levels increased during winter (I<sup>2</sup> = 28%, <i>p</i> < 0.001). These findings suggest that seasonal variations in FT3 levels are likely to be influenced by the winter temperature. Considering the important role of the FT3 in the nonshivering thermogenesis process, we assume that this observed pattern is probably related to the differences in use of thyroid hormones in the brown adipose tissue during adaptive thermogenesis, which may depend on intensity of cold exposure.https://www.mdpi.com/1422-0067/24/18/14052free triiodothyronine (FT3)seasonal variationsair temperaturepolar T3 syndromenonshivering thermogenesisbrown adipose tissue (BAT) |
| spellingShingle | Alena A. Nikanorova Nikolay A. Barashkov Vera G. Pshennikova Fedor M. Teryutin Sergey S. Nakhodkin Aisen V. Solovyev Georgii P. Romanov Tatiana E. Burtseva Sardana A. Fedorova A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis? International Journal of Molecular Sciences free triiodothyronine (FT3) seasonal variations air temperature polar T3 syndrome nonshivering thermogenesis brown adipose tissue (BAT) |
| title | A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis? |
| title_full | A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis? |
| title_fullStr | A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis? |
| title_full_unstemmed | A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis? |
| title_short | A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis? |
| title_sort | systematic review and meta analysis of free triiodothyronine ft3 levels in humans depending on seasonal air temperature changes is the variation in ft3 levels related to nonshivering thermogenesis |
| topic | free triiodothyronine (FT3) seasonal variations air temperature polar T3 syndrome nonshivering thermogenesis brown adipose tissue (BAT) |
| url | https://www.mdpi.com/1422-0067/24/18/14052 |
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