Nucleus accumbens local circuit for cue-dependent aversive learning
Summary: Response to threatening environmental stimuli requires detection and encoding of important environmental features that dictate threat. Aversive events are highly salient, which promotes associative learning about stimuli that signal this threat. The nucleus accumbens is uniquely positioned...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015000 |
| _version_ | 1797449466588954624 |
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| author | Andrew Belilos Cortez Gray Christie Sanders Destiny Black Elizabeth Mays Christopher Richie Ayesha Sengupta Holly Hake T. Chase Francis |
| author_facet | Andrew Belilos Cortez Gray Christie Sanders Destiny Black Elizabeth Mays Christopher Richie Ayesha Sengupta Holly Hake T. Chase Francis |
| author_sort | Andrew Belilos |
| collection | DOAJ |
| description | Summary: Response to threatening environmental stimuli requires detection and encoding of important environmental features that dictate threat. Aversive events are highly salient, which promotes associative learning about stimuli that signal this threat. The nucleus accumbens is uniquely positioned to process this salient, aversive information and promote motivated output, through plasticity on the major projection neurons in the brain area. We describe a nucleus accumbens core local circuit whereby excitatory plasticity facilitates learning and recall of discrete aversive cues. We demonstrate that putative nucleus accumbens substance P release and long-term excitatory plasticity on dopamine 2 receptor-expressing projection neurons are required for cue-dependent fear learning. Additionally, we find that fear learning and recall is dependent on distinct projection neuron subtypes. Our work demonstrates a critical role for nucleus accumbens substance P in cue-dependent aversive learning. |
| first_indexed | 2024-03-09T14:25:28Z |
| format | Article |
| id | doaj.art-0cfac47ff6be4fddaa2ad9c574a086d1 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-09T14:25:28Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-0cfac47ff6be4fddaa2ad9c574a086d12023-11-28T07:25:50ZengElsevierCell Reports2211-12472023-12-014212113488Nucleus accumbens local circuit for cue-dependent aversive learningAndrew Belilos0Cortez Gray1Christie Sanders2Destiny Black3Elizabeth Mays4Christopher Richie5Ayesha Sengupta6Holly Hake7T. Chase Francis8Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USADepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USADepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USADepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USAIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USADepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA; Corresponding authorSummary: Response to threatening environmental stimuli requires detection and encoding of important environmental features that dictate threat. Aversive events are highly salient, which promotes associative learning about stimuli that signal this threat. The nucleus accumbens is uniquely positioned to process this salient, aversive information and promote motivated output, through plasticity on the major projection neurons in the brain area. We describe a nucleus accumbens core local circuit whereby excitatory plasticity facilitates learning and recall of discrete aversive cues. We demonstrate that putative nucleus accumbens substance P release and long-term excitatory plasticity on dopamine 2 receptor-expressing projection neurons are required for cue-dependent fear learning. Additionally, we find that fear learning and recall is dependent on distinct projection neuron subtypes. Our work demonstrates a critical role for nucleus accumbens substance P in cue-dependent aversive learning.http://www.sciencedirect.com/science/article/pii/S2211124723015000CP: Neuroscience |
| spellingShingle | Andrew Belilos Cortez Gray Christie Sanders Destiny Black Elizabeth Mays Christopher Richie Ayesha Sengupta Holly Hake T. Chase Francis Nucleus accumbens local circuit for cue-dependent aversive learning Cell Reports CP: Neuroscience |
| title | Nucleus accumbens local circuit for cue-dependent aversive learning |
| title_full | Nucleus accumbens local circuit for cue-dependent aversive learning |
| title_fullStr | Nucleus accumbens local circuit for cue-dependent aversive learning |
| title_full_unstemmed | Nucleus accumbens local circuit for cue-dependent aversive learning |
| title_short | Nucleus accumbens local circuit for cue-dependent aversive learning |
| title_sort | nucleus accumbens local circuit for cue dependent aversive learning |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723015000 |
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