Increased TNF-alpha/IFN-gamma/IL-2 and decreased TNF-alpha/IFN-gamma production by central memory T cells are associated with protective responses against bovine tuberculosis following BCG vaccination

Increased TNF-alpha/IFN-gamma/IL-2 and decreased TNF-alpha/IFN-gamma production by central memory T cells are associated with protective responses against bovine tuberculosis following BCG vaccination

Central memory T cells (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses...

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Bibliographic Details
Main Authors: Mayara Fernanda Maggioli, Mitchell Palmer, Tyler C. Thacker, Hans Martin Vordermeier, Jodi L. McGill, Adam O. Whelan, Michelle H. Larsen, William R. Jacobs, W. Ray Waters
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
BCG Vaccine
polyfunctional T cells
bovine tuberculosis
Central memory T cells
calf model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00421/full

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