New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors
Dipeptidyl peptidase 8 (DPP8) and 9 (DPP9) are widely expressed in mammals including humans, mainly locate in the cytoplasm. The DPP8 and DPP9 (DPP8/9) belong to serine proteolytic enzymes, they can recognize and cleave N-terminal dipeptides of specific substrates if proline is at the penultimate po...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1002871/full |
| _version_ | 1818065386362372096 |
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| author | Chenkai Cui Xuefei Tian Linting Wei Yinhong Wang Kexin Wang Rongguo Fu |
| author_facet | Chenkai Cui Xuefei Tian Linting Wei Yinhong Wang Kexin Wang Rongguo Fu |
| author_sort | Chenkai Cui |
| collection | DOAJ |
| description | Dipeptidyl peptidase 8 (DPP8) and 9 (DPP9) are widely expressed in mammals including humans, mainly locate in the cytoplasm. The DPP8 and DPP9 (DPP8/9) belong to serine proteolytic enzymes, they can recognize and cleave N-terminal dipeptides of specific substrates if proline is at the penultimate position. Because the localization of DPP8/9 is different from that of DPP4 and the substrates for DPP8/9 are not yet completely clear, their physiological and pathological roles are still being further explored. In this article, we will review the recent research advances focusing on the expression, regulation, and functions of DPP8/9 in physiology and pathology status. Emerging research results have shown that DPP8/9 is involved in various biological processes such as cell behavior, energy metabolism, and immune regulation, which plays an essential role in maintaining normal development and physiological functions of the body. DPP8/9 is also involved in pathological processes such as tumorigenesis, inflammation, and organ fibrosis. In recent years, related research on immune cell pyroptosis has made DPP8/9 a new potential target for the treatment of hematological diseases. In addition, DPP8/9 inhibitors also have great potential in the treatment of tumors and chronic kidney disease. |
| first_indexed | 2024-12-10T14:51:04Z |
| format | Article |
| id | doaj.art-0cfc6abfcd934116b4eb02e1ec5a72e6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T14:51:04Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0cfc6abfcd934116b4eb02e1ec5a72e62022-12-22T01:44:26ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.10028711002871New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitorsChenkai Cui0Xuefei Tian1Linting Wei2Yinhong Wang3Kexin Wang4Rongguo Fu5Department of Nephrology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaSection of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United StatesDepartment of Nephrology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Nephrology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Nephrology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Nephrology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDipeptidyl peptidase 8 (DPP8) and 9 (DPP9) are widely expressed in mammals including humans, mainly locate in the cytoplasm. The DPP8 and DPP9 (DPP8/9) belong to serine proteolytic enzymes, they can recognize and cleave N-terminal dipeptides of specific substrates if proline is at the penultimate position. Because the localization of DPP8/9 is different from that of DPP4 and the substrates for DPP8/9 are not yet completely clear, their physiological and pathological roles are still being further explored. In this article, we will review the recent research advances focusing on the expression, regulation, and functions of DPP8/9 in physiology and pathology status. Emerging research results have shown that DPP8/9 is involved in various biological processes such as cell behavior, energy metabolism, and immune regulation, which plays an essential role in maintaining normal development and physiological functions of the body. DPP8/9 is also involved in pathological processes such as tumorigenesis, inflammation, and organ fibrosis. In recent years, related research on immune cell pyroptosis has made DPP8/9 a new potential target for the treatment of hematological diseases. In addition, DPP8/9 inhibitors also have great potential in the treatment of tumors and chronic kidney disease.https://www.frontiersin.org/articles/10.3389/fphar.2022.1002871/fullDPP8DPP9cell behaviorinflammationpyroptosiscancer |
| spellingShingle | Chenkai Cui Xuefei Tian Linting Wei Yinhong Wang Kexin Wang Rongguo Fu New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors Frontiers in Pharmacology DPP8 DPP9 cell behavior inflammation pyroptosis cancer |
| title | New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors |
| title_full | New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors |
| title_fullStr | New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors |
| title_full_unstemmed | New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors |
| title_short | New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors |
| title_sort | new insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors |
| topic | DPP8 DPP9 cell behavior inflammation pyroptosis cancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1002871/full |
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