CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease
Abstract Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin assembly. Meanwhile, it is highly related to cell c...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.644 |
| _version_ | 1818242312467120128 |
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| author | Miaomiao Jia Xueqin Zou Shuying Yin Weihong Tian Yangjing Zhao Hui Wang Guoying Xu Weili Cai Qixiang Shao |
| author_facet | Miaomiao Jia Xueqin Zou Shuying Yin Weihong Tian Yangjing Zhao Hui Wang Guoying Xu Weili Cai Qixiang Shao |
| author_sort | Miaomiao Jia |
| collection | DOAJ |
| description | Abstract Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin assembly. Meanwhile, it is highly related to cell cycle progression and the proceeding of malignancy. Most of the previous studies were focused on the function of CHD4 with tumor cells, cancer stem cells, and cancer cells multidrug resistance. Recently, some researchers have explored the CHD4 functions on the development and differentiation of adaptive immune cells, such as T and B lymphocytes. In this review, we will discuss details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHD4 in the pathogenesis of the autoimmune disease. |
| first_indexed | 2024-12-12T13:43:14Z |
| format | Article |
| id | doaj.art-0cfc99868da84ad6b33db27928df5488 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-12-12T13:43:14Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-0cfc99868da84ad6b33db27928df54882022-12-22T00:22:44ZengWileyImmunity, Inflammation and Disease2050-45272022-07-01107n/an/a10.1002/iid3.644CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune diseaseMiaomiao Jia0Xueqin Zou1Shuying Yin2Weihong Tian3Yangjing Zhao4Hui Wang5Guoying Xu6Weili Cai7Qixiang Shao8Reproductive Sciences Institute Jiangsu University Zhenjiang Jiangsu P.R. ChinaReproductive Sciences Institute Jiangsu University Zhenjiang Jiangsu P.R. ChinaReproductive Sciences Institute Jiangsu University Zhenjiang Jiangsu P.R. ChinaReproductive Sciences Institute Jiangsu University Zhenjiang Jiangsu P.R. ChinaReproductive Sciences Institute Jiangsu University Zhenjiang Jiangsu P.R. ChinaReproductive Sciences Institute Jiangsu University Zhenjiang Jiangsu P.R. ChinaSchool of Medical Science and Laboratory Medicine, Institute of Medical Genetics and Reproductive Immunity Jiangsu College of Nursing Huai'an Jiangsu P.R. ChinaSchool of Medical Science and Laboratory Medicine, Institute of Medical Genetics and Reproductive Immunity Jiangsu College of Nursing Huai'an Jiangsu P.R. ChinaReproductive Sciences Institute Jiangsu University Zhenjiang Jiangsu P.R. ChinaAbstract Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin assembly. Meanwhile, it is highly related to cell cycle progression and the proceeding of malignancy. Most of the previous studies were focused on the function of CHD4 with tumor cells, cancer stem cells, and cancer cells multidrug resistance. Recently, some researchers have explored the CHD4 functions on the development and differentiation of adaptive immune cells, such as T and B lymphocytes. In this review, we will discuss details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHD4 in the pathogenesis of the autoimmune disease.https://doi.org/10.1002/iid3.644autoimmune diseaseB cellschromodomain helicase DNA binding protein 4nucleosome remodeling and deacetylation complexT cells |
| spellingShingle | Miaomiao Jia Xueqin Zou Shuying Yin Weihong Tian Yangjing Zhao Hui Wang Guoying Xu Weili Cai Qixiang Shao CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease Immunity, Inflammation and Disease autoimmune disease B cells chromodomain helicase DNA binding protein 4 nucleosome remodeling and deacetylation complex T cells |
| title | CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease |
| title_full | CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease |
| title_fullStr | CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease |
| title_full_unstemmed | CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease |
| title_short | CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease |
| title_sort | chd4 orchestrates the symphony of t and b lymphocytes development and a good mediator in preventing from autoimmune disease |
| topic | autoimmune disease B cells chromodomain helicase DNA binding protein 4 nucleosome remodeling and deacetylation complex T cells |
| url | https://doi.org/10.1002/iid3.644 |
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