Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction.
Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these finding...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4569339?pdf=render |
| _version_ | 1819150635139858432 |
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| author | Shushimita Shushimita Pieter van der Pol Ron W F de Bruin Jan N M Ijzermans Cees van Kooten Frank J M F Dor |
| author_facet | Shushimita Shushimita Pieter van der Pol Ron W F de Bruin Jan N M Ijzermans Cees van Kooten Frank J M F Dor |
| author_sort | Shushimita Shushimita |
| collection | DOAJ |
| description | Preoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these findings, we investigated the effect of short-term DR (30% reduction of total food intake) or three days of water only fasting on MBL in 10-12 weeks old male C57/Bl6 mice. Both dietary regimens significantly reduce the circulating levels of MBL as well as its mRNA expression in liver, the sole production site of MBL. Reconstitution of MBL abolished the protection afforded by dietary restriction, whereas in the fasting group the protection persisted. These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different. |
| first_indexed | 2024-12-22T14:20:38Z |
| format | Article |
| id | doaj.art-0cfd77f5345d42bbbd0eeca19a8b0003 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T14:20:38Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0cfd77f5345d42bbbd0eeca19a8b00032022-12-21T18:22:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013779510.1371/journal.pone.0137795Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction.Shushimita ShushimitaPieter van der PolRon W F de BruinJan N M IjzermansCees van KootenFrank J M F DorPreoperative fasting and dietary restriction offer robust protection against renal ischemia/reperfusion injury (I/RI) in mice. We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these findings, we investigated the effect of short-term DR (30% reduction of total food intake) or three days of water only fasting on MBL in 10-12 weeks old male C57/Bl6 mice. Both dietary regimens significantly reduce the circulating levels of MBL as well as its mRNA expression in liver, the sole production site of MBL. Reconstitution of MBL abolished the protection afforded by dietary restriction, whereas in the fasting group the protection persisted. These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different.http://europepmc.org/articles/PMC4569339?pdf=render |
| spellingShingle | Shushimita Shushimita Pieter van der Pol Ron W F de Bruin Jan N M Ijzermans Cees van Kooten Frank J M F Dor Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. PLoS ONE |
| title | Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. |
| title_full | Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. |
| title_fullStr | Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. |
| title_full_unstemmed | Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. |
| title_short | Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction. |
| title_sort | mannan binding lectin is involved in the protection against renal ischemia reperfusion injury by dietary restriction |
| url | http://europepmc.org/articles/PMC4569339?pdf=render |
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