Role of the microbiome and its metabolites in ankylosing spondylitis
Ankylosing spondylitis (AS), a chronic condition that commonly influences the spine and sacroiliac joints, usually progresses to stiffness and progressive functional limitation. Its fundamental etiology and pathogenesis are likely multifactorial and remain elusive. As environmental factors, gut micr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1010572/full |
| _version_ | 1828133394673827840 |
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| author | Zi-Yi Song Zi-Yi Song Zi-Yi Song Duo Yuan Sheng-Xiao Zhang Sheng-Xiao Zhang Sheng-Xiao Zhang |
| author_facet | Zi-Yi Song Zi-Yi Song Zi-Yi Song Duo Yuan Sheng-Xiao Zhang Sheng-Xiao Zhang Sheng-Xiao Zhang |
| author_sort | Zi-Yi Song |
| collection | DOAJ |
| description | Ankylosing spondylitis (AS), a chronic condition that commonly influences the spine and sacroiliac joints, usually progresses to stiffness and progressive functional limitation. Its fundamental etiology and pathogenesis are likely multifactorial and remain elusive. As environmental factors, gut microbiota performs critical functions in the pathogenesis of AS through various mechanisms, including interacting with genes, enhancing intestinal permeability, activating the gut mucosa immune system, and affecting the intestinal microbiota metabolites. This review provides an overview of recent advances in investigating gut microbiota in AS pathogenesis and discusses potential methods for future therapeutic intervention. |
| first_indexed | 2024-04-11T17:18:45Z |
| format | Article |
| id | doaj.art-0cfeb24d821549059b84caac018a691c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T17:18:45Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0cfeb24d821549059b84caac018a691c2022-12-22T04:12:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10105721010572Role of the microbiome and its metabolites in ankylosing spondylitisZi-Yi Song0Zi-Yi Song1Zi-Yi Song2Duo Yuan3Sheng-Xiao Zhang4Sheng-Xiao Zhang5Sheng-Xiao Zhang6Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, ChinaShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, The Second Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Gynecology and Obstetrics, The Second Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, ChinaShanxi Provincial Key Laboratory of Rheumatism Immune Microecology, The Second Hospital of Shanxi Medical University, Taiyuan, ChinaAnkylosing spondylitis (AS), a chronic condition that commonly influences the spine and sacroiliac joints, usually progresses to stiffness and progressive functional limitation. Its fundamental etiology and pathogenesis are likely multifactorial and remain elusive. As environmental factors, gut microbiota performs critical functions in the pathogenesis of AS through various mechanisms, including interacting with genes, enhancing intestinal permeability, activating the gut mucosa immune system, and affecting the intestinal microbiota metabolites. This review provides an overview of recent advances in investigating gut microbiota in AS pathogenesis and discusses potential methods for future therapeutic intervention.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1010572/fullankylosing spondylitisHLA-B27microbiotamicrobiomemicrobial metabolites |
| spellingShingle | Zi-Yi Song Zi-Yi Song Zi-Yi Song Duo Yuan Sheng-Xiao Zhang Sheng-Xiao Zhang Sheng-Xiao Zhang Role of the microbiome and its metabolites in ankylosing spondylitis Frontiers in Immunology ankylosing spondylitis HLA-B27 microbiota microbiome microbial metabolites |
| title | Role of the microbiome and its metabolites in ankylosing spondylitis |
| title_full | Role of the microbiome and its metabolites in ankylosing spondylitis |
| title_fullStr | Role of the microbiome and its metabolites in ankylosing spondylitis |
| title_full_unstemmed | Role of the microbiome and its metabolites in ankylosing spondylitis |
| title_short | Role of the microbiome and its metabolites in ankylosing spondylitis |
| title_sort | role of the microbiome and its metabolites in ankylosing spondylitis |
| topic | ankylosing spondylitis HLA-B27 microbiota microbiome microbial metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1010572/full |
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