Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications

Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications

The Warburg effect is known as the hyperactive glycolysis that provides the energy needed for rapid growth and proliferation in most tumor cells even under the condition of sufficient oxygen. This metabolic pattern can lead to a large accumulation of lactic acid and intracellular acidification, whic...

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Bibliographic Details
Main Authors:	Qixin Duan, Shuang Zhang, Yang Wang, Dongming Lu, Yingming Sun, Yongyang Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	monocarboxylate transporters lactate tumor metabolism metastasis angiogenesis tumor microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.1069555/full

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