Biomarkers in premature calves with and without respiratory distress syndrome
Abstract Background Approaches to the evaluation of pulmonary arterial hypertension (PAH) in premature calves by using lung‐specific epithelial and endothelial biomarkers are needed. Objective To investigate the evaluation of PAH in premature calves with and without respiratory distress syndrome (RD...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.16217 |
| _version_ | 1818888062068850688 |
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| author | Merve Ider Amir Naseri Mahmut Ok Kamil Uney Alper Erturk Murat K. Durgut Tugba M. Parlak Nimet Ismailoglu Muhammed M. Kapar |
| author_facet | Merve Ider Amir Naseri Mahmut Ok Kamil Uney Alper Erturk Murat K. Durgut Tugba M. Parlak Nimet Ismailoglu Muhammed M. Kapar |
| author_sort | Merve Ider |
| collection | DOAJ |
| description | Abstract Background Approaches to the evaluation of pulmonary arterial hypertension (PAH) in premature calves by using lung‐specific epithelial and endothelial biomarkers are needed. Objective To investigate the evaluation of PAH in premature calves with and without respiratory distress syndrome (RDS) by using lung‐specific epithelial and endothelial biomarkers and determine the prognostic value of these markers in premature calves. Animals Fifty premature calves with RDS, 20 non‐RDS premature calves, and 10 healthy term calves. Methods Hypoxia, hypercapnia, and tachypnea were considered criteria for RDS. Arterial blood gases (PaO2, PaCO2, oxygen saturation [SO2], base excess [BE], and serum lactate concentration) were measured to assess hypoxia. Serum concentrations of lung‐specific growth differentiation factor‐15 (GDF‐15), asymmetric dimethylarginine (ADMA), endothelin‐1 (ET‐1), vascular endothelial growth factor (VEGF), and surfactant protein D (SP‐D) were measured to assess PAH. Results Arterial blood pH, PaO2, SO2, and BE of premature calves with RDS were significantly lower and PaCO2 and lactate concentrations higher compared to non‐RDS premature and healthy calves. The ADMA and SP‐D concentrations of premature calves with RDS were lower and serum ET‐1 concentrations higher than those of non‐RDS premature and healthy calves. No statistical differences for GDF‐15 and VEGF were found among groups. Conclusions and Clinical Importance Significant increases in serum ET‐1 concentrations and decreases in ADMA and SP‐D concentrations highlight the utility of these markers in the diagnosis of PAH in premature calves with RDS. Also, we found that ET‐1 was a reliable diagnostic and prognostic biomarker for PAH and predicting mortality in premature calves. |
| first_indexed | 2024-12-19T16:47:09Z |
| format | Article |
| id | doaj.art-0d005a0212e9412cabf751a9e761d50d |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-19T16:47:09Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-0d005a0212e9412cabf751a9e761d50d2022-12-21T20:13:38ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-09-013552524253310.1111/jvim.16217Biomarkers in premature calves with and without respiratory distress syndromeMerve Ider0Amir Naseri1Mahmut Ok2Kamil Uney3Alper Erturk4Murat K. Durgut5Tugba M. Parlak6Nimet Ismailoglu7Muhammed M. Kapar8Faculty of Veterinary Medicine, Department of Internal Medicine Selcuk University Konya TurkeyFaculty of Veterinary Medicine, Department of Internal Medicine Selcuk University Konya TurkeyFaculty of Veterinary Medicine, Department of Internal Medicine Selcuk University Konya TurkeyFaculty of Veterinary Medicine, Department of Pharmacology and Toxicology Selcuk University Konya TurkeyFaculty of Veterinary Medicine, Department of Internal Medicine Mustafa Kemal University Hatay TurkeyFaculty of Veterinary Medicine, Department of Internal Medicine Selcuk University Konya TurkeyFaculty of Veterinary Medicine, Department of Pharmacology and Toxicology Selcuk University Konya TurkeyFaculty of Veterinary Medicine, Department of Internal Medicine Selcuk University Konya TurkeyFaculty of Veterinary Medicine, Department of Internal Medicine Selcuk University Konya TurkeyAbstract Background Approaches to the evaluation of pulmonary arterial hypertension (PAH) in premature calves by using lung‐specific epithelial and endothelial biomarkers are needed. Objective To investigate the evaluation of PAH in premature calves with and without respiratory distress syndrome (RDS) by using lung‐specific epithelial and endothelial biomarkers and determine the prognostic value of these markers in premature calves. Animals Fifty premature calves with RDS, 20 non‐RDS premature calves, and 10 healthy term calves. Methods Hypoxia, hypercapnia, and tachypnea were considered criteria for RDS. Arterial blood gases (PaO2, PaCO2, oxygen saturation [SO2], base excess [BE], and serum lactate concentration) were measured to assess hypoxia. Serum concentrations of lung‐specific growth differentiation factor‐15 (GDF‐15), asymmetric dimethylarginine (ADMA), endothelin‐1 (ET‐1), vascular endothelial growth factor (VEGF), and surfactant protein D (SP‐D) were measured to assess PAH. Results Arterial blood pH, PaO2, SO2, and BE of premature calves with RDS were significantly lower and PaCO2 and lactate concentrations higher compared to non‐RDS premature and healthy calves. The ADMA and SP‐D concentrations of premature calves with RDS were lower and serum ET‐1 concentrations higher than those of non‐RDS premature and healthy calves. No statistical differences for GDF‐15 and VEGF were found among groups. Conclusions and Clinical Importance Significant increases in serum ET‐1 concentrations and decreases in ADMA and SP‐D concentrations highlight the utility of these markers in the diagnosis of PAH in premature calves with RDS. Also, we found that ET‐1 was a reliable diagnostic and prognostic biomarker for PAH and predicting mortality in premature calves.https://doi.org/10.1111/jvim.16217endothelial biomarkerspremature calfpulmonary epitheliumpulmonary hypertensionRDS |
| spellingShingle | Merve Ider Amir Naseri Mahmut Ok Kamil Uney Alper Erturk Murat K. Durgut Tugba M. Parlak Nimet Ismailoglu Muhammed M. Kapar Biomarkers in premature calves with and without respiratory distress syndrome Journal of Veterinary Internal Medicine endothelial biomarkers premature calf pulmonary epithelium pulmonary hypertension RDS |
| title | Biomarkers in premature calves with and without respiratory distress syndrome |
| title_full | Biomarkers in premature calves with and without respiratory distress syndrome |
| title_fullStr | Biomarkers in premature calves with and without respiratory distress syndrome |
| title_full_unstemmed | Biomarkers in premature calves with and without respiratory distress syndrome |
| title_short | Biomarkers in premature calves with and without respiratory distress syndrome |
| title_sort | biomarkers in premature calves with and without respiratory distress syndrome |
| topic | endothelial biomarkers premature calf pulmonary epithelium pulmonary hypertension RDS |
| url | https://doi.org/10.1111/jvim.16217 |
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