Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques
Even though synthetic colorants can cause side effects such as allergies and pigmentation, they have not been sufficiently researched. Herein, high-performance liquid chromatography, liquid chromatography-tandem mass spectrometry, and liquid chromatography-quadrupole time-of-flight mass spectrometry...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/10/5967 |
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| author | Kyoung-Moon Han You Kyung Kim Sowoon Seo Jun Hyoung Kim Ji Hyun Lee Hyung Il Kim Sooyeul Cho |
| author_facet | Kyoung-Moon Han You Kyung Kim Sowoon Seo Jun Hyoung Kim Ji Hyun Lee Hyung Il Kim Sooyeul Cho |
| author_sort | Kyoung-Moon Han |
| collection | DOAJ |
| description | Even though synthetic colorants can cause side effects such as allergies and pigmentation, they have not been sufficiently researched. Herein, high-performance liquid chromatography, liquid chromatography-tandem mass spectrometry, and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) were used to detect 13 banned synthetic colorants in cosmetics and characterize their fragmentation. The developed HPLC method was validated following the International Conference on Harmonisation guidelines (specificity, limit of detection, limit of quantification, recovery, linearity, accuracy, and precision) and applied to 120 distributed cosmetic products, one of which was found to contain three illegal synthetic colorants, namely Basic Blue 26 (0.33 mg/g), Basic Red 2 (0.53 mg/g), and Basic Yellow 28 (31.50 mg/g). Additionally, based on their fragment ions obtained using LC-Q-TOF-MS, the fragmentation pattern of synthetic colorants was predicted. Thus, our work paves the way for the reliable detection of illegal synthetic colorants and may help to prevent the distribution of cosmetics containing the same. |
| first_indexed | 2024-03-11T03:58:17Z |
| format | Article |
| id | doaj.art-0d011ce131164fe6bac094544b2f3423 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T03:58:17Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-0d011ce131164fe6bac094544b2f34232023-11-18T00:18:30ZengMDPI AGApplied Sciences2076-34172023-05-011310596710.3390/app13105967Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric TechniquesKyoung-Moon Han0You Kyung Kim1Sowoon Seo2Jun Hyoung Kim3Ji Hyun Lee4Hyung Il Kim5Sooyeul Cho6Center for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of KoreaCenter for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of KoreaCenter for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of KoreaCenter for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of KoreaCenter for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of KoreaCenter for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of KoreaCenter for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of KoreaEven though synthetic colorants can cause side effects such as allergies and pigmentation, they have not been sufficiently researched. Herein, high-performance liquid chromatography, liquid chromatography-tandem mass spectrometry, and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) were used to detect 13 banned synthetic colorants in cosmetics and characterize their fragmentation. The developed HPLC method was validated following the International Conference on Harmonisation guidelines (specificity, limit of detection, limit of quantification, recovery, linearity, accuracy, and precision) and applied to 120 distributed cosmetic products, one of which was found to contain three illegal synthetic colorants, namely Basic Blue 26 (0.33 mg/g), Basic Red 2 (0.53 mg/g), and Basic Yellow 28 (31.50 mg/g). Additionally, based on their fragment ions obtained using LC-Q-TOF-MS, the fragmentation pattern of synthetic colorants was predicted. Thus, our work paves the way for the reliable detection of illegal synthetic colorants and may help to prevent the distribution of cosmetics containing the same.https://www.mdpi.com/2076-3417/13/10/5967cosmeticssynthetic colorantsmethod developmentLC-Q-TOF-MSMS fragmentation |
| spellingShingle | Kyoung-Moon Han You Kyung Kim Sowoon Seo Jun Hyoung Kim Ji Hyun Lee Hyung Il Kim Sooyeul Cho Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques Applied Sciences cosmetics synthetic colorants method development LC-Q-TOF-MS MS fragmentation |
| title | Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques |
| title_full | Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques |
| title_fullStr | Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques |
| title_full_unstemmed | Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques |
| title_short | Analysis of 13 Banned Colorants in Cosmetics via Liquid Chromatographic and Mass Spectrometric Techniques |
| title_sort | analysis of 13 banned colorants in cosmetics via liquid chromatographic and mass spectrometric techniques |
| topic | cosmetics synthetic colorants method development LC-Q-TOF-MS MS fragmentation |
| url | https://www.mdpi.com/2076-3417/13/10/5967 |
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