Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming
The vulnerability of the mammalian brain is mainly due to its limited ability to generate new neurons once fully matured. Direct conversion of non-neuronal cells to neurons opens up a new avenue for therapeutic intervention and has made great strides also for in vivo applications in the injured brai...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996120304496 |
| _version_ | 1828911175762444288 |
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| author | Stefan H. Stricker Magdalena Götz |
| author_facet | Stefan H. Stricker Magdalena Götz |
| author_sort | Stefan H. Stricker |
| collection | DOAJ |
| description | The vulnerability of the mammalian brain is mainly due to its limited ability to generate new neurons once fully matured. Direct conversion of non-neuronal cells to neurons opens up a new avenue for therapeutic intervention and has made great strides also for in vivo applications in the injured brain. These great achievements raise the issue of adequate identity and chromatin hallmarks of the induced neurons. This may be particularly important, as aberrant epigenetic settings may reveal their adverse effects only in certain brain activity states. Therefore, we review here the knowledge about epigenetic memory and partially resetting of chromatin hallmarks from other reprogramming fields, before moving to the knowledge in direct neuronal reprogramming, which is still limited. Most importantly, novel tools are available now to manipulate specific epigenetic marks at specific sites of the genome. Applying these will eventually allow erasing aberrant epigenetic memory and paving the way towards new therapeutic approaches for brain repair. |
| first_indexed | 2024-12-13T18:58:19Z |
| format | Article |
| id | doaj.art-0d015882066447ba8bb971fae3b64cf7 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-13T18:58:19Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-0d015882066447ba8bb971fae3b64cf72022-12-21T23:34:45ZengElsevierNeurobiology of Disease1095-953X2021-01-01148105174Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogrammingStefan H. Stricker0Magdalena Götz1Institute for Stem Cell Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, 82152 Planegg, Germany; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians Universitaet Muenchen, 82152 Planegg, Munich, Germany; MCN Junior Research Group, Munich Center for Neurosciences, Ludwig-Maximilian-Universität, BioMedical Center, Grosshaderner Strasse 9, Planegg-Martinsried 82152, Germany; Corresponding authors.Institute for Stem Cell Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, 82152 Planegg, Germany; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians Universitaet Muenchen, 82152 Planegg, Munich, Germany; SYNERGY, Excellence Cluster of Systems Neurology, BioMedical Center (BMC), Ludwig-Maximilians-Universitaet Muenchen, 82152 Planegg, Munich, GermanyThe vulnerability of the mammalian brain is mainly due to its limited ability to generate new neurons once fully matured. Direct conversion of non-neuronal cells to neurons opens up a new avenue for therapeutic intervention and has made great strides also for in vivo applications in the injured brain. These great achievements raise the issue of adequate identity and chromatin hallmarks of the induced neurons. This may be particularly important, as aberrant epigenetic settings may reveal their adverse effects only in certain brain activity states. Therefore, we review here the knowledge about epigenetic memory and partially resetting of chromatin hallmarks from other reprogramming fields, before moving to the knowledge in direct neuronal reprogramming, which is still limited. Most importantly, novel tools are available now to manipulate specific epigenetic marks at specific sites of the genome. Applying these will eventually allow erasing aberrant epigenetic memory and paving the way towards new therapeutic approaches for brain repair.http://www.sciencedirect.com/science/article/pii/S0969996120304496Direct reprogrammingEpigeneticsNeural lineage |
| spellingShingle | Stefan H. Stricker Magdalena Götz Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming Neurobiology of Disease Direct reprogramming Epigenetics Neural lineage |
| title | Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming |
| title_full | Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming |
| title_fullStr | Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming |
| title_full_unstemmed | Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming |
| title_short | Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming |
| title_sort | epigenetic regulation of neural lineage elaboration implications for therapeutic reprogramming |
| topic | Direct reprogramming Epigenetics Neural lineage |
| url | http://www.sciencedirect.com/science/article/pii/S0969996120304496 |
| work_keys_str_mv | AT stefanhstricker epigeneticregulationofneurallineageelaborationimplicationsfortherapeuticreprogramming AT magdalenagotz epigeneticregulationofneurallineageelaborationimplicationsfortherapeuticreprogramming |