Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects
In a randomized double-blind crossover trial, the effect of 8 week supplementation with grape and wine polyphenols on functional and structural vascular parameters and autonomic activity was evaluated in 40 essential hypertensive patients treated with diuretic monotherapy. Ambulatory blood pressure,...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616303164 |
| _version_ | 1818723361356775424 |
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| author | Arno Greyling Rosa M. Bruno Richard Draijer Theo Mulder Dick H.J. Thijssen Stefano Taddei Agostino Virdis Lorenzo Ghiadoni |
| author_facet | Arno Greyling Rosa M. Bruno Richard Draijer Theo Mulder Dick H.J. Thijssen Stefano Taddei Agostino Virdis Lorenzo Ghiadoni |
| author_sort | Arno Greyling |
| collection | DOAJ |
| description | In a randomized double-blind crossover trial, the effect of 8 week supplementation with grape and wine polyphenols on functional and structural vascular parameters and autonomic activity was evaluated in 40 essential hypertensive patients treated with diuretic monotherapy. Ambulatory blood pressure, brachial artery flow mediated dilation (FMD) and pulse-wave velocity (PWV) were measured at baseline and after each 8-week intervention. Forearm resistance artery endothelial function and muscle sympathetic nerve activity (MSNA) response to mental stress and cold-pressor test were measured in two separate sub-groups. No statistically significant differences were found across time or between groups in either blood pressure, FMD, PWV, or resistance artery endothelial function. The MSNA response to the two stressors was non-significantly attenuated after grape-wine polyphenol supplementation. These results do not support the hypothesis that daily consumption of a high dose of grape and wine polyphenols lowers blood pressure or affects vascular function in patients already on antihypertensive medication. |
| first_indexed | 2024-12-17T21:09:18Z |
| format | Article |
| id | doaj.art-0d0173cf201a43d78937bd95c93ba517 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T21:09:18Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0d0173cf201a43d78937bd95c93ba5172022-12-21T21:32:29ZengElsevierJournal of Functional Foods1756-46462016-12-0127448460Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjectsArno Greyling0Rosa M. Bruno1Richard Draijer2Theo Mulder3Dick H.J. Thijssen4Stefano Taddei5Agostino Virdis6Lorenzo Ghiadoni7Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands; Unilever R&D Vlaardingen, The Netherlands; Corresponding author. Unilever Research and Development Vlaardingen, Vlaardingen, The Netherlands. Fax: +31 104605993.Department of Clinical and Experimental Medicine, University of Pisa, ItalyUnilever R&D Vlaardingen, The NetherlandsUnilever R&D Vlaardingen, The NetherlandsDepartment of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands; Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, United KingdomDepartment of Clinical and Experimental Medicine, University of Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, ItalyIn a randomized double-blind crossover trial, the effect of 8 week supplementation with grape and wine polyphenols on functional and structural vascular parameters and autonomic activity was evaluated in 40 essential hypertensive patients treated with diuretic monotherapy. Ambulatory blood pressure, brachial artery flow mediated dilation (FMD) and pulse-wave velocity (PWV) were measured at baseline and after each 8-week intervention. Forearm resistance artery endothelial function and muscle sympathetic nerve activity (MSNA) response to mental stress and cold-pressor test were measured in two separate sub-groups. No statistically significant differences were found across time or between groups in either blood pressure, FMD, PWV, or resistance artery endothelial function. The MSNA response to the two stressors was non-significantly attenuated after grape-wine polyphenol supplementation. These results do not support the hypothesis that daily consumption of a high dose of grape and wine polyphenols lowers blood pressure or affects vascular function in patients already on antihypertensive medication.http://www.sciencedirect.com/science/article/pii/S1756464616303164WineGrapePolyphenolCardiovascular diseaseEndothelial functionBlood pressure |
| spellingShingle | Arno Greyling Rosa M. Bruno Richard Draijer Theo Mulder Dick H.J. Thijssen Stefano Taddei Agostino Virdis Lorenzo Ghiadoni Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects Journal of Functional Foods Wine Grape Polyphenol Cardiovascular disease Endothelial function Blood pressure |
| title | Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects |
| title_full | Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects |
| title_fullStr | Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects |
| title_full_unstemmed | Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects |
| title_short | Effects of wine and grape polyphenols on blood pressure, endothelial function and sympathetic nervous system activity in treated hypertensive subjects |
| title_sort | effects of wine and grape polyphenols on blood pressure endothelial function and sympathetic nervous system activity in treated hypertensive subjects |
| topic | Wine Grape Polyphenol Cardiovascular disease Endothelial function Blood pressure |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616303164 |
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