Advances in Microfluidics for Single Red Blood Cell Analysis
The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/1/117 |
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| author | Georgii V. Grigorev Alexander V. Lebedev Xiaohao Wang Xiang Qian George V. Maksimov Liwei Lin |
| author_facet | Georgii V. Grigorev Alexander V. Lebedev Xiaohao Wang Xiang Qian George V. Maksimov Liwei Lin |
| author_sort | Georgii V. Grigorev |
| collection | DOAJ |
| description | The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. The limitations and drawbacks of each technology are addressed and future prospects are discussed. |
| first_indexed | 2024-03-09T13:23:58Z |
| format | Article |
| id | doaj.art-0d085b1dab9340ad9e95fad77f54fee1 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:23:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-0d085b1dab9340ad9e95fad77f54fee12023-11-30T21:25:44ZengMDPI AGBiosensors2079-63742023-01-0113111710.3390/bios13010117Advances in Microfluidics for Single Red Blood Cell AnalysisGeorgii V. Grigorev0Alexander V. Lebedev1Xiaohao Wang2Xiang Qian3George V. Maksimov4Liwei Lin5Data Science and Information Technology Research Center, Tsinghua Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, ChinaMachine Building Department, Bauman Moscow State University, 105005 Moscow, RussiaShenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaShenzhen International Graduate School, Tsinghua University, Shenzhen 518055, ChinaFaculty of Biology, Lomonosov Moscow State University, 119991 Moscow, RussiaMechanical Engineering Department, University of California in Berkeley, Berkeley, CA 94720, USAThe utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. The limitations and drawbacks of each technology are addressed and future prospects are discussed.https://www.mdpi.com/2079-6374/13/1/117RBCred blood cellerythrocytesingle cellmicrofluidicsmedicine |
| spellingShingle | Georgii V. Grigorev Alexander V. Lebedev Xiaohao Wang Xiang Qian George V. Maksimov Liwei Lin Advances in Microfluidics for Single Red Blood Cell Analysis Biosensors RBC red blood cell erythrocyte single cell microfluidics medicine |
| title | Advances in Microfluidics for Single Red Blood Cell Analysis |
| title_full | Advances in Microfluidics for Single Red Blood Cell Analysis |
| title_fullStr | Advances in Microfluidics for Single Red Blood Cell Analysis |
| title_full_unstemmed | Advances in Microfluidics for Single Red Blood Cell Analysis |
| title_short | Advances in Microfluidics for Single Red Blood Cell Analysis |
| title_sort | advances in microfluidics for single red blood cell analysis |
| topic | RBC red blood cell erythrocyte single cell microfluidics medicine |
| url | https://www.mdpi.com/2079-6374/13/1/117 |
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