Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists
Signalling through pattern recognition receptors (PRRs) leads to strong proinflammatory responses, enhancing the activity of antigen presenting cells and shaping adaptive immune responses against tumour associated antigens. Unfortunately, toxicities associated with systemic administration of these a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/12/3824 |
| _version_ | 1797544278814097408 |
|---|---|
| author | Olivia K. Burn Kef K. Prasit Ian F. Hermans |
| author_facet | Olivia K. Burn Kef K. Prasit Ian F. Hermans |
| author_sort | Olivia K. Burn |
| collection | DOAJ |
| description | Signalling through pattern recognition receptors (PRRs) leads to strong proinflammatory responses, enhancing the activity of antigen presenting cells and shaping adaptive immune responses against tumour associated antigens. Unfortunately, toxicities associated with systemic administration of these agonists have limited their clinical use to date. Direct injection of PRR agonists into the tumour can enhance immune responses by directly modulating the cells present in the tumour microenvironment. This can improve local antitumour activity, but importantly, also facilitates systemic responses that limit tumour growth at distant sites. As such, this form of therapy could be used clinically where metastatic tumour lesions are accessible, or as neoadjuvant therapy. In this review, we summarise current preclinical data on intratumoural administration of PRR agonists, including new strategies to optimise delivery and impact, and combination studies with current and promising new cancer therapies. |
| first_indexed | 2024-03-10T13:57:46Z |
| format | Article |
| id | doaj.art-0d0c885f4ee14eccbb9c5f1c45080c6b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:57:46Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0d0c885f4ee14eccbb9c5f1c45080c6b2023-11-21T01:25:04ZengMDPI AGCancers2072-66942020-12-011212382410.3390/cancers12123824Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor AgonistsOlivia K. Burn0Kef K. Prasit1Ian F. Hermans2Malaghan Institute of Medical Research, P.O. Box 7060, Wellington 6042, New ZealandMalaghan Institute of Medical Research, P.O. Box 7060, Wellington 6042, New ZealandMalaghan Institute of Medical Research, P.O. Box 7060, Wellington 6042, New ZealandSignalling through pattern recognition receptors (PRRs) leads to strong proinflammatory responses, enhancing the activity of antigen presenting cells and shaping adaptive immune responses against tumour associated antigens. Unfortunately, toxicities associated with systemic administration of these agonists have limited their clinical use to date. Direct injection of PRR agonists into the tumour can enhance immune responses by directly modulating the cells present in the tumour microenvironment. This can improve local antitumour activity, but importantly, also facilitates systemic responses that limit tumour growth at distant sites. As such, this form of therapy could be used clinically where metastatic tumour lesions are accessible, or as neoadjuvant therapy. In this review, we summarise current preclinical data on intratumoural administration of PRR agonists, including new strategies to optimise delivery and impact, and combination studies with current and promising new cancer therapies.https://www.mdpi.com/2072-6694/12/12/3824pattern-recognition receptorstoll-like receptorsintratumouraltumour microenvironment |
| spellingShingle | Olivia K. Burn Kef K. Prasit Ian F. Hermans Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists Cancers pattern-recognition receptors toll-like receptors intratumoural tumour microenvironment |
| title | Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists |
| title_full | Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists |
| title_fullStr | Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists |
| title_full_unstemmed | Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists |
| title_short | Modulating the Tumour Microenvironment by Intratumoural Injection of Pattern Recognition Receptor Agonists |
| title_sort | modulating the tumour microenvironment by intratumoural injection of pattern recognition receptor agonists |
| topic | pattern-recognition receptors toll-like receptors intratumoural tumour microenvironment |
| url | https://www.mdpi.com/2072-6694/12/12/3824 |
| work_keys_str_mv | AT oliviakburn modulatingthetumourmicroenvironmentbyintratumouralinjectionofpatternrecognitionreceptoragonists AT kefkprasit modulatingthetumourmicroenvironmentbyintratumouralinjectionofpatternrecognitionreceptoragonists AT ianfhermans modulatingthetumourmicroenvironmentbyintratumouralinjectionofpatternrecognitionreceptoragonists |