Synthesis of New Azetidine and Oxetane Amino Acid Derivatives through Aza-Michael Addition of NH-Heterocycles with Methyl 2-(Azetidin- or Oxetan-3-Ylidene)Acetates

Synthesis of New Azetidine and Oxetane Amino Acid Derivatives through Aza-Michael Addition of NH-Heterocycles with Methyl 2-(Azetidin- or Oxetan-3-Ylidene)Acetates

In this paper, a simple and efficient synthetic route for the preparation of new heterocyclic amino acid derivatives containing azetidine and oxetane rings was described. The starting (<i>N</i>-Boc-azetidin-3-ylidene)acetate was obtained from (<i>N</i>-Boc)azetidin-3-one by t...

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Bibliographic Details
Main Authors: Emilis Gudelis, Sonata Krikštolaitytė, Monika Stančiauskaitė, Urtė Šachlevičiūtė, Aurimas Bieliauskas, Vaida Milišiūnaitė, Rokas Jankauskas, Neringa Kleizienė, Frank A. Sløk, Algirdas Šačkus
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
azetidine
oxetane
heterocyclic amines
heterocyclic amino acids
aza-Michael addition
Suzuki–Miyaura cross-coupling reaction
Online Access:https://www.mdpi.com/1420-3049/28/3/1091

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