Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study
In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home...
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MDPI AG
2022-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/11/2361 |
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| author | Eline Meyers Ellen Deschepper Els Duysburgh Liselore De Rop Tine De Burghgraeve Pauline Van Ngoc Marina Digregorio Simon Delogne Anja Coen Nele De Clercq Laëtitia Buret Samuel Coenen An De Sutter Beatrice Scholtes Jan Y Verbakel Piet Cools Stefan Heytens |
| author_facet | Eline Meyers Ellen Deschepper Els Duysburgh Liselore De Rop Tine De Burghgraeve Pauline Van Ngoc Marina Digregorio Simon Delogne Anja Coen Nele De Clercq Laëtitia Buret Samuel Coenen An De Sutter Beatrice Scholtes Jan Y Verbakel Piet Cools Stefan Heytens |
| author_sort | Eline Meyers |
| collection | DOAJ |
| description | In the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home residents and 1082 vaccinated staff from 69 nursing homes in Belgium, we assessed the proportion having SARS-CoV-2 antibodies approximately two (April 2021), four (June 2021), and six months (August 2021) after a two-dose regimen of the BNT162b2 vaccine. We measured the seroprevalence using SARS-CoV-2 antibody rapid tests and collected socio-demographic and COVID-19 medical data using an online questionnaire. Two months after vaccination (baseline), we found a seroprevalence of 91% (95% CI: 89–93) among vaccinated residents and 99% (95% CI: 98–99) among vaccinated staff. Six months after vaccination, the seroprevalence significantly decreased to 68% (95% CI: 64–72) among residents and to 89% (95% CI; 86–91) among staff (<i>p</i> < 0.001). The seroprevalence was more likely to decrease among infection-naive residents, older residents, or residents with a high care dependency level. These findings emphasize the need for close monitoring of nursing home residents, as a substantial part of this population fails to mount a persistent antibody response after BNT162b2 vaccination. |
| first_indexed | 2024-03-09T18:33:50Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T18:33:50Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-0d0d8a0a2ee24a8fbc7f55b2c71e46c02023-11-24T07:15:56ZengMDPI AGViruses1999-49152022-10-011411236110.3390/v14112361Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort StudyEline Meyers0Ellen Deschepper1Els Duysburgh2Liselore De Rop3Tine De Burghgraeve4Pauline Van Ngoc5Marina Digregorio6Simon Delogne7Anja Coen8Nele De Clercq9Laëtitia Buret10Samuel Coenen11An De Sutter12Beatrice Scholtes13Jan Y Verbakel14Piet Cools15Stefan Heytens16Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, BelgiumBiostatistics Unit, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, BelgiumDepartment of Epidemiology and Public Health, Sciensano, 1000 Brussels, BelgiumEPI-Centre, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, BelgiumEPI-Centre, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, BelgiumResearch Unit of Primary Care and Health, Department of General Medicine, Faculty of Medicine, University of Liège, 4000 Liège, BelgiumResearch Unit of Primary Care and Health, Department of General Medicine, Faculty of Medicine, University of Liège, 4000 Liège, BelgiumResearch Unit of Primary Care and Health, Department of General Medicine, Faculty of Medicine, University of Liège, 4000 Liège, BelgiumDepartment of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, BelgiumDepartment of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, BelgiumResearch Unit of Primary Care and Health, Department of General Medicine, Faculty of Medicine, University of Liège, 4000 Liège, BelgiumDepartment of Family Medicine & Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, 2000 Antwerp, BelgiumDepartment of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, BelgiumResearch Unit of Primary Care and Health, Department of General Medicine, Faculty of Medicine, University of Liège, 4000 Liège, BelgiumEPI-Centre, Department of Public Health and Primary Care, KU Leuven, 3000 Leuven, BelgiumDepartment of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, BelgiumDepartment of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, BelgiumIn the SCOPE study, we monitored SARS-CoV-2 antibodies in a national sample of residents and staff from Belgian nursing homes. Here, we report the seroprevalence among infected and infection-naive residents and staff after the primary COVID-19 vaccination campaign. Among 1554 vaccinated nursing home residents and 1082 vaccinated staff from 69 nursing homes in Belgium, we assessed the proportion having SARS-CoV-2 antibodies approximately two (April 2021), four (June 2021), and six months (August 2021) after a two-dose regimen of the BNT162b2 vaccine. We measured the seroprevalence using SARS-CoV-2 antibody rapid tests and collected socio-demographic and COVID-19 medical data using an online questionnaire. Two months after vaccination (baseline), we found a seroprevalence of 91% (95% CI: 89–93) among vaccinated residents and 99% (95% CI: 98–99) among vaccinated staff. Six months after vaccination, the seroprevalence significantly decreased to 68% (95% CI: 64–72) among residents and to 89% (95% CI; 86–91) among staff (<i>p</i> < 0.001). The seroprevalence was more likely to decrease among infection-naive residents, older residents, or residents with a high care dependency level. These findings emphasize the need for close monitoring of nursing home residents, as a substantial part of this population fails to mount a persistent antibody response after BNT162b2 vaccination.https://www.mdpi.com/1999-4915/14/11/2361seroprevalenceSARS-CoV-2IgGIgMnursing home residentselderly |
| spellingShingle | Eline Meyers Ellen Deschepper Els Duysburgh Liselore De Rop Tine De Burghgraeve Pauline Van Ngoc Marina Digregorio Simon Delogne Anja Coen Nele De Clercq Laëtitia Buret Samuel Coenen An De Sutter Beatrice Scholtes Jan Y Verbakel Piet Cools Stefan Heytens Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study Viruses seroprevalence SARS-CoV-2 IgG IgM nursing home residents elderly |
| title | Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study |
| title_full | Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study |
| title_fullStr | Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study |
| title_full_unstemmed | Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study |
| title_short | Declining Prevalence of SARS-CoV-2 Antibodies among Vaccinated Nursing Home Residents and Staff Six Months after the Primary BNT162b2 Vaccination Campaign in Belgium: A Prospective Cohort Study |
| title_sort | declining prevalence of sars cov 2 antibodies among vaccinated nursing home residents and staff six months after the primary bnt162b2 vaccination campaign in belgium a prospective cohort study |
| topic | seroprevalence SARS-CoV-2 IgG IgM nursing home residents elderly |
| url | https://www.mdpi.com/1999-4915/14/11/2361 |
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