Breaking enhancers to gain insights into developmental defects
Despite ground-breaking genetic studies that have identified thousands of risk variants for developmental diseases, how these variants lead to molecular and cellular phenotypes remains a gap in knowledge. Many of these variants are non-coding and occur at enhancers, which orchestrate key regulatory...
Main Authors: | Daniel A Armendariz, Anjana Sundarrajan, Gary C Hon |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-07-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/88187 |
Similar Items
-
Computational identification of clonal cells in single-cell CRISPR screens
by: Yihan Wang, et al.
Published: (2022-02-01) -
CHD-associated enhancers shape human cardiomyocyte lineage commitment
by: Daniel A Armendariz, et al.
Published: (2023-04-01) -
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors
by: Joseph M Replogle, et al.
Published: (2022-12-01) -
CRISPR-Cas9-Mediated Genomic Deletions Protocol in Zebrafish
by: João Pedro Amorim, et al.
Published: (2020-12-01) -
Prime Editing: Genome Editing for Rare Genetic Diseases Without Double-Strand Breaks or Donor DNA
by: Ianis G. Matsoukas, et al.
Published: (2020-06-01)