Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis
Background: Current evidences show an increased risk of white matter hyperintensities (WMHs) in migraineurs compared to age-matched controls. However, WMHs prevalence and the associations between WMHs and clinical characteristics in migraineurs have not been systematically evaluated using a meta-ana...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223000013 |
| _version_ | 1797869731647062016 |
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| author | Wenyuan Zhang Zicheng Cheng Fangwang Fu Zhenxiang Zhan |
| author_facet | Wenyuan Zhang Zicheng Cheng Fangwang Fu Zhenxiang Zhan |
| author_sort | Wenyuan Zhang |
| collection | DOAJ |
| description | Background: Current evidences show an increased risk of white matter hyperintensities (WMHs) in migraineurs compared to age-matched controls. However, WMHs prevalence and the associations between WMHs and clinical characteristics in migraineurs have not been systematically evaluated using a meta-analytical approach. This study explored the pooled prevalence of WMHs and the associations of WMHs with the clinical characteristics in patients with migraine. Methods: A systematic review and meta-analysis of observational studies reporting the occurrence and clinical characteristics of patients with WMHs attributed to migraine was performed. We searched the PubMed, Web of Science, and Embase databases. Random-effects models were used to calculate the pooled prevalence rate, odds ratio (OR), or mean difference (MD) with corresponding 95% confidence intervals (CIs). Results: Thirty eligible studies were identified including 3,502 migraineurs aged 37.2 (mean) years. The pooled WMHs prevalence was 44 %, 45 %, and 38 % in migraine, migraine with aura, and migraine without aura groups, respectively. In migraineurs with WMHs, the frontal lobe and subcortical white matter were the most susceptible area. Compared with non-migraine controls, patients with migraine had increased odds for WMHs (OR 4.32, 95 % CI = 2.56–7.28, I2 = 67 %). According to reported univariable results from included studies, pooled analysis showed that clinical characteristics including age, presence of aura, disease duration, hypertension, diabetes mellitus and right-to-left shunt were associated with the presence of WMHs. Migraine pain and aura characteristics were not related to WMHs. Conclusions: These data suggest that WMHs are common in migraine, especially in those who are older or have aura, hypertension, diabetes mellitus, or right-to-left shunt. A better understanding of the WMHs attributed to migraine is needed in future studies. |
| first_indexed | 2024-04-10T00:17:34Z |
| format | Article |
| id | doaj.art-0d1ab9f928a74df0a8411ee45afec510 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-10T00:17:34Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-0d1ab9f928a74df0a8411ee45afec5102023-03-16T05:04:01ZengElsevierNeuroImage: Clinical2213-15822023-01-0137103312Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysisWenyuan Zhang0Zicheng Cheng1Fangwang Fu2Zhenxiang Zhan3Department of Neurology, Affiliated Yueqing Hospital, Wenzhou Medical University, Yueqing, China; Corresponding author at: Department of Neurology, Affiliated Yueqing Hospital, Wenzhou Medical University, No.338 Qingyuan Road, Yueqing, Zhejiang Province 325600, China.Department of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, ChinaDepartment of Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, ChinaBackground: Current evidences show an increased risk of white matter hyperintensities (WMHs) in migraineurs compared to age-matched controls. However, WMHs prevalence and the associations between WMHs and clinical characteristics in migraineurs have not been systematically evaluated using a meta-analytical approach. This study explored the pooled prevalence of WMHs and the associations of WMHs with the clinical characteristics in patients with migraine. Methods: A systematic review and meta-analysis of observational studies reporting the occurrence and clinical characteristics of patients with WMHs attributed to migraine was performed. We searched the PubMed, Web of Science, and Embase databases. Random-effects models were used to calculate the pooled prevalence rate, odds ratio (OR), or mean difference (MD) with corresponding 95% confidence intervals (CIs). Results: Thirty eligible studies were identified including 3,502 migraineurs aged 37.2 (mean) years. The pooled WMHs prevalence was 44 %, 45 %, and 38 % in migraine, migraine with aura, and migraine without aura groups, respectively. In migraineurs with WMHs, the frontal lobe and subcortical white matter were the most susceptible area. Compared with non-migraine controls, patients with migraine had increased odds for WMHs (OR 4.32, 95 % CI = 2.56–7.28, I2 = 67 %). According to reported univariable results from included studies, pooled analysis showed that clinical characteristics including age, presence of aura, disease duration, hypertension, diabetes mellitus and right-to-left shunt were associated with the presence of WMHs. Migraine pain and aura characteristics were not related to WMHs. Conclusions: These data suggest that WMHs are common in migraine, especially in those who are older or have aura, hypertension, diabetes mellitus, or right-to-left shunt. A better understanding of the WMHs attributed to migraine is needed in future studies.http://www.sciencedirect.com/science/article/pii/S2213158223000013MigraineWhite matter hyperintensitiesPrevalence rateCerebral small vessel diseaseHeadache |
| spellingShingle | Wenyuan Zhang Zicheng Cheng Fangwang Fu Zhenxiang Zhan Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis NeuroImage: Clinical Migraine White matter hyperintensities Prevalence rate Cerebral small vessel disease Headache |
| title | Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis |
| title_full | Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis |
| title_fullStr | Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis |
| title_full_unstemmed | Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis |
| title_short | Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis |
| title_sort | prevalence and clinical characteristics of white matter hyperintensities in migraine a meta analysis |
| topic | Migraine White matter hyperintensities Prevalence rate Cerebral small vessel disease Headache |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223000013 |
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