On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations
Central neurotrauma, such as spinal cord injury or traumatic brain injury, can damage critical axonal pathways and neurons and lead to partial to complete loss of neural function that is difficult to address in the mature central nervous system. Improvement and innovation in the development, manufac...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00602/full |
| _version_ | 1818154518594977792 |
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| author | Samantha Wu Kevin T. FitzGerald Kevin T. FitzGerald James Giordano James Giordano |
| author_facet | Samantha Wu Kevin T. FitzGerald Kevin T. FitzGerald James Giordano James Giordano |
| author_sort | Samantha Wu |
| collection | DOAJ |
| description | Central neurotrauma, such as spinal cord injury or traumatic brain injury, can damage critical axonal pathways and neurons and lead to partial to complete loss of neural function that is difficult to address in the mature central nervous system. Improvement and innovation in the development, manufacture, and delivery of stem-cell based therapies, as well as the continued exploration of newer forms of stem cells, have allowed the professional and public spheres to resolve technical and ethical questions that previously hindered stem cell research for central nervous system injury. Recent in vitro and in vivo models have demonstrated the potential that reprogrammed autologous stem cells, in particular, have to restore functionality and induce regeneration—while potentially mitigating technical issues of immunogenicity, rejection, and ethical issues of embryonic derivation. These newer stem-cell based approaches are not, however, without concerns and problems of safety, efficacy, use and distribution. This review is an assessment of the current state of the science, the potential solutions that have been and are currently being explored, and the problems and questions that arise from what appears to be a promising way forward (i.e., autologous stem cell-based therapies)—for the purpose of advancing the research for much-needed therapeutic interventions for central neurotrauma. |
| first_indexed | 2024-12-11T14:27:47Z |
| format | Article |
| id | doaj.art-0d1c63d0352e4faaaf518d775202229f |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T14:27:47Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0d1c63d0352e4faaaf518d775202229f2022-12-22T01:02:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-08-01910.3389/fneur.2018.00602338168On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and SpeculationsSamantha Wu0Kevin T. FitzGerald1Kevin T. FitzGerald2James Giordano3James Giordano4Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC, United StatesPellegrino Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC, United StatesDepartment of Oncology, Georgetown University Medical Center, Washington, DC, United StatesPellegrino Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC, United StatesDepartments of Neurology and Biochemistry, Georgetown University Medical Center, Washington, DC, United StatesCentral neurotrauma, such as spinal cord injury or traumatic brain injury, can damage critical axonal pathways and neurons and lead to partial to complete loss of neural function that is difficult to address in the mature central nervous system. Improvement and innovation in the development, manufacture, and delivery of stem-cell based therapies, as well as the continued exploration of newer forms of stem cells, have allowed the professional and public spheres to resolve technical and ethical questions that previously hindered stem cell research for central nervous system injury. Recent in vitro and in vivo models have demonstrated the potential that reprogrammed autologous stem cells, in particular, have to restore functionality and induce regeneration—while potentially mitigating technical issues of immunogenicity, rejection, and ethical issues of embryonic derivation. These newer stem-cell based approaches are not, however, without concerns and problems of safety, efficacy, use and distribution. This review is an assessment of the current state of the science, the potential solutions that have been and are currently being explored, and the problems and questions that arise from what appears to be a promising way forward (i.e., autologous stem cell-based therapies)—for the purpose of advancing the research for much-needed therapeutic interventions for central neurotrauma.https://www.frontiersin.org/article/10.3389/fneur.2018.00602/fullnervous system traumaneural stem cellsautologous transplantationregenerationcell and tissue based therapyspinal cord injury |
| spellingShingle | Samantha Wu Kevin T. FitzGerald Kevin T. FitzGerald James Giordano James Giordano On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations Frontiers in Neurology nervous system trauma neural stem cells autologous transplantation regeneration cell and tissue based therapy spinal cord injury |
| title | On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations |
| title_full | On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations |
| title_fullStr | On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations |
| title_full_unstemmed | On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations |
| title_short | On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations |
| title_sort | on the viability and potential value of stem cells for repair and treatment of central neurotrauma overview and speculations |
| topic | nervous system trauma neural stem cells autologous transplantation regeneration cell and tissue based therapy spinal cord injury |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00602/full |
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