Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity
Abstract Background To evaluate the outcome of intravitreal bevacizumab (IVB) and aflibercept (IVA) injection for patients with retinopathy of prematurity (ROP). Methods In this single-center retrospective cohort, the recorded medical data of the infants who had been undergone intravitreal injection...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | International Journal of Retina and Vitreous |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40942-021-00334-4 |
| _version_ | 1819022290566774784 |
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| author | Hamid Riazi-esfahani Alireza Mahmoudi Mehdi Sanatkar Afsar Dastjani Farahani Fatemeh Bazvand |
| author_facet | Hamid Riazi-esfahani Alireza Mahmoudi Mehdi Sanatkar Afsar Dastjani Farahani Fatemeh Bazvand |
| author_sort | Hamid Riazi-esfahani |
| collection | DOAJ |
| description | Abstract Background To evaluate the outcome of intravitreal bevacizumab (IVB) and aflibercept (IVA) injection for patients with retinopathy of prematurity (ROP). Methods In this single-center retrospective cohort, the recorded medical data of the infants who had been undergone intravitreal injection with either bevacizumab or aflibercept for type 1 ROP were reviewed. The infants were allocated into two groups. IVB group included patients who were treated with bevacizumab as initial treatment and the IVA group included patients who were treated with aflibercept as initial treatment. The rate and time of complete regression, as well as the recurrence rates, were compared between the groups. Results A total of 889 eyes of 453 infants were enrolled in the study. There were 865 eyes of 441 infants in the IVB group and 24 eyes of 12 infants in the IVA group. Follow-up time was 289 ± 257 days in the IVB group and 143 ± 25 days in the IVA group (p < 0.001). The difference in the ROP zone was not statistically significant between the 2 treatment groups (p = 0.328). All eyes in the IVA group showed initial regression of ROP after the intravitreal injections. These regressions were achieved in 830 (96.0%) eyes that were injected with IVB (p = 0.023). The median observed regression time was 10 days and 16 days in eyes treated with bevacizumab and aflibercept respectively. Recurrence was noted in 3.9% of eyes (34/865) in the IVB group and 58.3% of eyes (14/24) in the IVA group (p < 0.001). Conclusion While the regression rate in the IVA group was significantly higher than in the IVB group, the recurrence rate was significantly more in the IVA group, which may be attributed to differences in the pharmacokinetics of these drugs in the vitreous body. |
| first_indexed | 2024-12-21T04:20:39Z |
| format | Article |
| id | doaj.art-0d1cede6083749d398b214f57d4abcfd |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-12-21T04:20:39Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-0d1cede6083749d398b214f57d4abcfd2022-12-21T19:16:10ZengBMCInternational Journal of Retina and Vitreous2056-99202021-10-01711710.1186/s40942-021-00334-4Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurityHamid Riazi-esfahani0Alireza Mahmoudi1Mehdi Sanatkar2Afsar Dastjani Farahani3Fatemeh Bazvand4Eye Research Center, Farabi Eye Hospital, Tehran University of Medical ScienceEye Research Center, Farabi Eye Hospital, Tehran University of Medical ScienceEye Research Center, Farabi Eye Hospital, Tehran University of Medical ScienceEye Research Center, Farabi Eye Hospital, Tehran University of Medical ScienceEye Research Center, Farabi Eye Hospital, Tehran University of Medical ScienceAbstract Background To evaluate the outcome of intravitreal bevacizumab (IVB) and aflibercept (IVA) injection for patients with retinopathy of prematurity (ROP). Methods In this single-center retrospective cohort, the recorded medical data of the infants who had been undergone intravitreal injection with either bevacizumab or aflibercept for type 1 ROP were reviewed. The infants were allocated into two groups. IVB group included patients who were treated with bevacizumab as initial treatment and the IVA group included patients who were treated with aflibercept as initial treatment. The rate and time of complete regression, as well as the recurrence rates, were compared between the groups. Results A total of 889 eyes of 453 infants were enrolled in the study. There were 865 eyes of 441 infants in the IVB group and 24 eyes of 12 infants in the IVA group. Follow-up time was 289 ± 257 days in the IVB group and 143 ± 25 days in the IVA group (p < 0.001). The difference in the ROP zone was not statistically significant between the 2 treatment groups (p = 0.328). All eyes in the IVA group showed initial regression of ROP after the intravitreal injections. These regressions were achieved in 830 (96.0%) eyes that were injected with IVB (p = 0.023). The median observed regression time was 10 days and 16 days in eyes treated with bevacizumab and aflibercept respectively. Recurrence was noted in 3.9% of eyes (34/865) in the IVB group and 58.3% of eyes (14/24) in the IVA group (p < 0.001). Conclusion While the regression rate in the IVA group was significantly higher than in the IVB group, the recurrence rate was significantly more in the IVA group, which may be attributed to differences in the pharmacokinetics of these drugs in the vitreous body.https://doi.org/10.1186/s40942-021-00334-4Retinopathy of prematurityBevacizumabAflibercept |
| spellingShingle | Hamid Riazi-esfahani Alireza Mahmoudi Mehdi Sanatkar Afsar Dastjani Farahani Fatemeh Bazvand Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity International Journal of Retina and Vitreous Retinopathy of prematurity Bevacizumab Aflibercept |
| title | Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity |
| title_full | Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity |
| title_fullStr | Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity |
| title_full_unstemmed | Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity |
| title_short | Comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity |
| title_sort | comparison of aflibercept and bevacizumab in the treatment of type 1 retinopathy of prematurity |
| topic | Retinopathy of prematurity Bevacizumab Aflibercept |
| url | https://doi.org/10.1186/s40942-021-00334-4 |
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