A candidate gene identification strategy utilizing mouse to human big-data mining: “3R-tenet” in COPD genetic research

A candidate gene identification strategy utilizing mouse to human big-data mining: “3R-tenet” in COPD genetic research

Abstract Background Early life impairments leading to lower lung function by adulthood are considered as risk factors for chronic obstructive pulmonary disease (COPD). Recently, we compared the lung transcriptomic profile between two mouse strains with extreme total lung capacities to identify plaus...

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Bibliographic Details
Main Authors: Sangeetha Vishweswaraiah, Leema George, Natarajan Purushothaman, Koustav Ganguly
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Respiratory Research
Subjects:
3R
Alternate models
COPD
Asthma
Lung
Gene
Online Access:http://link.springer.com/article/10.1186/s12931-018-0795-y

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