Spinal cord injury causes chronic bone marrow failure
Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and d...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17564-z |
| _version_ | 1818834671956393984 |
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| author | Randall S. Carpenter Jessica M. Marbourg Faith H. Brennan Katherine A. Mifflin Jodie C. E. Hall Roselyn R. Jiang Xiaokui M. Mo Malith Karunasiri Matthew H. Burke Adrienne M. Dorrance Phillip G. Popovich |
| author_facet | Randall S. Carpenter Jessica M. Marbourg Faith H. Brennan Katherine A. Mifflin Jodie C. E. Hall Roselyn R. Jiang Xiaokui M. Mo Malith Karunasiri Matthew H. Burke Adrienne M. Dorrance Phillip G. Popovich |
| author_sort | Randall S. Carpenter |
| collection | DOAJ |
| description | Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis. |
| first_indexed | 2024-12-19T02:38:32Z |
| format | Article |
| id | doaj.art-0d1de6f876b2431485cb553f43443b20 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:38:32Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0d1de6f876b2431485cb553f43443b202022-12-21T20:39:15ZengNature PortfolioNature Communications2041-17232020-07-0111111310.1038/s41467-020-17564-zSpinal cord injury causes chronic bone marrow failureRandall S. Carpenter0Jessica M. Marbourg1Faith H. Brennan2Katherine A. Mifflin3Jodie C. E. Hall4Roselyn R. Jiang5Xiaokui M. Mo6Malith Karunasiri7Matthew H. Burke8Adrienne M. Dorrance9Phillip G. Popovich10Neuroscience Graduate Program, The Ohio State UniversityNeuroscience Graduate Program, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversityCenter for Biostatistics and Bioinformatics, The Ohio State UniversityComprehensive Cancer Center, The Ohio State UniversityComprehensive Cancer Center, The Ohio State UniversityComprehensive Cancer Center, The Ohio State UniversityDepartment of Neuroscience, The Ohio State UniversitySpinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis.https://doi.org/10.1038/s41467-020-17564-z |
| spellingShingle | Randall S. Carpenter Jessica M. Marbourg Faith H. Brennan Katherine A. Mifflin Jodie C. E. Hall Roselyn R. Jiang Xiaokui M. Mo Malith Karunasiri Matthew H. Burke Adrienne M. Dorrance Phillip G. Popovich Spinal cord injury causes chronic bone marrow failure Nature Communications |
| title | Spinal cord injury causes chronic bone marrow failure |
| title_full | Spinal cord injury causes chronic bone marrow failure |
| title_fullStr | Spinal cord injury causes chronic bone marrow failure |
| title_full_unstemmed | Spinal cord injury causes chronic bone marrow failure |
| title_short | Spinal cord injury causes chronic bone marrow failure |
| title_sort | spinal cord injury causes chronic bone marrow failure |
| url | https://doi.org/10.1038/s41467-020-17564-z |
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