Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway

Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway

Abstract Background Microglia-derived lysosomal cathepsins are important inflammatory mediators to trigger signaling pathways in inflammation-related cascades. Our previous study showed that the expression of cathepsin C (CatC) in the brain is induced predominantly in activated microglia in neuroinf...

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Bibliographic Details
Main Authors: Qing Liu, Yanli Zhang, Shuang Liu, Yanna Liu, Xiaohan Yang, Gang Liu, Takahiro Shimizu, Kazuhiro Ikenaka, Kai Fan, Jianmei Ma
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Microglia
Cathepsin C
Cytokine
NR2B
Online Access:http://link.springer.com/article/10.1186/s12974-019-1398-3

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