BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis
Maturing male germ cells undergo a unique developmental process in spermiogenesis that replaces nucleosomal histones with protamines, the process of which is critical for testicular development and male fertility. The progress of this exchange is regulated by complex mechanisms that are not well und...
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/4/1985 |
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| author | Chao Huang Huan Gong Bin Mu Xinting Lan Chengcheng Yang Jinlong Tan Wentao Liu Yuanfeng Zou Lixia Li Bin Feng Xia He Qihui Luo Zhengli Chen |
| author_facet | Chao Huang Huan Gong Bin Mu Xinting Lan Chengcheng Yang Jinlong Tan Wentao Liu Yuanfeng Zou Lixia Li Bin Feng Xia He Qihui Luo Zhengli Chen |
| author_sort | Chao Huang |
| collection | DOAJ |
| description | Maturing male germ cells undergo a unique developmental process in spermiogenesis that replaces nucleosomal histones with protamines, the process of which is critical for testicular development and male fertility. The progress of this exchange is regulated by complex mechanisms that are not well understood. Now, with mouse genetic models, we show that barrier-to-autointegration factor-like protein (BAF-L) plays an important role in spermiogenesis and spermatozoal function. BAF-L is a male germ cell marker, whose expression is highly associated with the maturation of male germ cells. The genetic deletion of BAF-L in mice impairs the progress of spermiogenesis and thus male fertility. This effect on male fertility is a consequence of the disturbed homeostasis of histones and protamines in maturing male germ cells, in which the interactions between BAF-L and histones/protamines are implicated. Finally, we show that reduced testicular expression of BAF-L represents a risk factor of human male infertility. |
| first_indexed | 2024-03-09T21:45:40Z |
| format | Article |
| id | doaj.art-0d1f038a2f2e4f98ab84bba84925556b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:45:40Z |
| publishDate | 2022-02-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0d1f038a2f2e4f98ab84bba84925556b2023-11-23T20:17:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01234198510.3390/ijms23041985BAF-L Modulates Histone-to-Protamine Transition during SpermiogenesisChao Huang0Huan Gong1Bin Mu2Xinting Lan3Chengcheng Yang4Jinlong Tan5Wentao Liu6Yuanfeng Zou7Lixia Li8Bin Feng9Xia He10Qihui Luo11Zhengli Chen12Laboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, ChinaAnimal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaLaboratory of Experimental Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaMaturing male germ cells undergo a unique developmental process in spermiogenesis that replaces nucleosomal histones with protamines, the process of which is critical for testicular development and male fertility. The progress of this exchange is regulated by complex mechanisms that are not well understood. Now, with mouse genetic models, we show that barrier-to-autointegration factor-like protein (BAF-L) plays an important role in spermiogenesis and spermatozoal function. BAF-L is a male germ cell marker, whose expression is highly associated with the maturation of male germ cells. The genetic deletion of BAF-L in mice impairs the progress of spermiogenesis and thus male fertility. This effect on male fertility is a consequence of the disturbed homeostasis of histones and protamines in maturing male germ cells, in which the interactions between BAF-L and histones/protamines are implicated. Finally, we show that reduced testicular expression of BAF-L represents a risk factor of human male infertility.https://www.mdpi.com/1422-0067/23/4/1985BAF-Lspermiogenesishistonesprotaminesmale infertility |
| spellingShingle | Chao Huang Huan Gong Bin Mu Xinting Lan Chengcheng Yang Jinlong Tan Wentao Liu Yuanfeng Zou Lixia Li Bin Feng Xia He Qihui Luo Zhengli Chen BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis International Journal of Molecular Sciences BAF-L spermiogenesis histones protamines male infertility |
| title | BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis |
| title_full | BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis |
| title_fullStr | BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis |
| title_full_unstemmed | BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis |
| title_short | BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis |
| title_sort | baf l modulates histone to protamine transition during spermiogenesis |
| topic | BAF-L spermiogenesis histones protamines male infertility |
| url | https://www.mdpi.com/1422-0067/23/4/1985 |
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