Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney
Zsolt Razga Department of Pathology, University of Szeged, Szeged, HungaryCorrespondence: Zsolt RazgaDepartment of Pathology, University of Szeged, Állomás U. 2, Szeged H 6725, HungaryTel/ Fax +36 62 545162Email razga.zsolt@med.u-szeged.huAbstract: Glomerular filtration rate is...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-06-01
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| Series: | International Journal of Nephrology and Renovascular Disease |
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| Online Access: | https://www.dovepress.com/functional-relevancies-of-trans-differentiation-in-the-juxtaglomerular-peer-reviewed-article-IJNRD |
| _version_ | 1818870917699207168 |
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| author | Razga Z |
| author_facet | Razga Z |
| author_sort | Razga Z |
| collection | DOAJ |
| description | Zsolt Razga Department of Pathology, University of Szeged, Szeged, HungaryCorrespondence: Zsolt RazgaDepartment of Pathology, University of Szeged, Állomás U. 2, Szeged H 6725, HungaryTel/ Fax +36 62 545162Email razga.zsolt@med.u-szeged.huAbstract: Glomerular filtration rate is controlled by the contractile effect of angiotensin II on afferent and efferent arterioles. The renin positivity of the afferent arterioles depends on tubuloglomerular feedback via the macula densa (MD) and short loop feedback via the afferent arteriolar endothelia. The renin-producing cells are trans-differentiated from smooth muscle cells (SMCs) of mainly the afferent arterioles, the MD cells are trans-differentiated from the neighboring tubular cells, and the high-permeability endothelial cells are trans-differentiated from normal permeability endothelial cells facing the renin-negative part of the afferent arterioles. All of the trans-differentiations depend on the activity of the renin-angiotensin system (RAS). The distribution of AT1 receptors for angiotensin II expresses the contractile effects of angiotensin II on renin-negative SMCs and the negative effect on trans-differentiation of renin-positive SMCs and MD cells. The purpose of this review is to summarize the stereological data of molecules like angiotensin II AT1 receptors, L-type calcium channels, and renin receptors in the juxtaglomerular apparatus of normal and STZ-induced diabetic rat kidneys, thus showing their functional relevancies on trans-differentiation among the juxtaglomerular apparatus’ elements.Keywords: angiotensin II, renin, trans-differentiation, kidney, arteriole, afferent arteriole, efferent arteriole, tubuloglomerular feedback, macula densa |
| first_indexed | 2024-12-19T12:14:39Z |
| format | Article |
| id | doaj.art-0d1f13a0088d4b219d48eda63f805ef9 |
| institution | Directory Open Access Journal |
| issn | 1178-7058 |
| language | English |
| last_indexed | 2024-12-19T12:14:39Z |
| publishDate | 2020-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nephrology and Renovascular Disease |
| spelling | doaj.art-0d1f13a0088d4b219d48eda63f805ef92022-12-21T20:22:03ZengDove Medical PressInternational Journal of Nephrology and Renovascular Disease1178-70582020-06-01Volume 1314715654497Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat KidneyRazga ZZsolt Razga Department of Pathology, University of Szeged, Szeged, HungaryCorrespondence: Zsolt RazgaDepartment of Pathology, University of Szeged, Állomás U. 2, Szeged H 6725, HungaryTel/ Fax +36 62 545162Email razga.zsolt@med.u-szeged.huAbstract: Glomerular filtration rate is controlled by the contractile effect of angiotensin II on afferent and efferent arterioles. The renin positivity of the afferent arterioles depends on tubuloglomerular feedback via the macula densa (MD) and short loop feedback via the afferent arteriolar endothelia. The renin-producing cells are trans-differentiated from smooth muscle cells (SMCs) of mainly the afferent arterioles, the MD cells are trans-differentiated from the neighboring tubular cells, and the high-permeability endothelial cells are trans-differentiated from normal permeability endothelial cells facing the renin-negative part of the afferent arterioles. All of the trans-differentiations depend on the activity of the renin-angiotensin system (RAS). The distribution of AT1 receptors for angiotensin II expresses the contractile effects of angiotensin II on renin-negative SMCs and the negative effect on trans-differentiation of renin-positive SMCs and MD cells. The purpose of this review is to summarize the stereological data of molecules like angiotensin II AT1 receptors, L-type calcium channels, and renin receptors in the juxtaglomerular apparatus of normal and STZ-induced diabetic rat kidneys, thus showing their functional relevancies on trans-differentiation among the juxtaglomerular apparatus’ elements.Keywords: angiotensin II, renin, trans-differentiation, kidney, arteriole, afferent arteriole, efferent arteriole, tubuloglomerular feedback, macula densahttps://www.dovepress.com/functional-relevancies-of-trans-differentiation-in-the-juxtaglomerular-peer-reviewed-article-IJNRDangiotensin iirenintrans-differentiationkideneyarterioleafferent arterioleefferent arterioletubulo glomerular feedbackmacula densarenin granulationpermeabiltyendothel; |
| spellingShingle | Razga Z Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney International Journal of Nephrology and Renovascular Disease angiotensin ii renin trans-differentiation kideney arteriole afferent arteriole efferent arteriole tubulo glomerular feedback macula densa renin granulation permeabilty endothel; |
| title | Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney |
| title_full | Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney |
| title_fullStr | Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney |
| title_full_unstemmed | Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney |
| title_short | Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney |
| title_sort | functional relevancies of trans differentiation in the juxtaglomerular apparatus of rat kidney |
| topic | angiotensin ii renin trans-differentiation kideney arteriole afferent arteriole efferent arteriole tubulo glomerular feedback macula densa renin granulation permeabilty endothel; |
| url | https://www.dovepress.com/functional-relevancies-of-trans-differentiation-in-the-juxtaglomerular-peer-reviewed-article-IJNRD |
| work_keys_str_mv | AT razgaz functionalrelevanciesoftransdifferentiationinthejuxtaglomerularapparatusofratkidney |