Concentration-Dependent Decitabine Effects on Primary NK Cells Viability, Phenotype, and Function in the Absence of Obvious NK Cells Proliferation–Original Article

Concentration-Dependent Decitabine Effects on Primary NK Cells Viability, Phenotype, and Function in the Absence of Obvious NK Cells Proliferation–Original Article

Acute myeloid leukemia (AML) cells can evade innate immune killing by modulating natural killer (NK) cells receptors and their cognate ligands in tumor cells, thus it may be possible to restore proper expression of immune receptors or ligands with immune sensitive drugs. Decitabine, as a hypomethyla...

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Bibliographic Details
Main Authors: Xiang Li, Min Zhang, Sisi Cai, Yaohui Wu, Yong You, Xianghong Wang, Li Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
acute myeloid leukemia
natural killer cells
decitabine
p-ERK
P-STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.755662/full

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