Pyroptosis, metabolism, and tumor immune microenvironment
Abstract In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-08-01
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| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctm2.492 |
| _version_ | 1819135484657401856 |
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| author | Tiantian Du Jie Gao Peilong Li Yunshan Wang Qiuchen Qi Xiaoyan Liu Juan Li Chuanxin Wang Lutao Du |
| author_facet | Tiantian Du Jie Gao Peilong Li Yunshan Wang Qiuchen Qi Xiaoyan Liu Juan Li Chuanxin Wang Lutao Du |
| author_sort | Tiantian Du |
| collection | DOAJ |
| description | Abstract In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic players in fate decisions of pyroptotic cells. Whether inflammatory characteristics induced by pyroptosis could cause damage the host or improve immune activity is largely dependent on the context, timing, and response degree. Here, we systematically review current points involved in regulatory mechanisms and the multidimensional roles of pyroptosis in several metabolic diseases and the tumor microenvironment. Targeting pyroptosis may reveal potential therapeutic avenues. |
| first_indexed | 2024-12-22T10:19:49Z |
| format | Article |
| id | doaj.art-0d259a3fba64427c8fcd1534ae094a9d |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-12-22T10:19:49Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-0d259a3fba64427c8fcd1534ae094a9d2022-12-21T18:29:39ZengWileyClinical and Translational Medicine2001-13262021-08-01118n/an/a10.1002/ctm2.492Pyroptosis, metabolism, and tumor immune microenvironmentTiantian Du0Jie Gao1Peilong Li2Yunshan Wang3Qiuchen Qi4Xiaoyan Liu5Juan Li6Chuanxin Wang7Lutao Du8Department of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaDepartment of Clinical Laboratory The Second Hospital Cheeloo College of Medicine Shandong University Jinan Shandong ChinaAbstract In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic players in fate decisions of pyroptotic cells. Whether inflammatory characteristics induced by pyroptosis could cause damage the host or improve immune activity is largely dependent on the context, timing, and response degree. Here, we systematically review current points involved in regulatory mechanisms and the multidimensional roles of pyroptosis in several metabolic diseases and the tumor microenvironment. Targeting pyroptosis may reveal potential therapeutic avenues.https://doi.org/10.1002/ctm2.492gasderminmetabolismpyroptosistumor immunitytumor microenvironment |
| spellingShingle | Tiantian Du Jie Gao Peilong Li Yunshan Wang Qiuchen Qi Xiaoyan Liu Juan Li Chuanxin Wang Lutao Du Pyroptosis, metabolism, and tumor immune microenvironment Clinical and Translational Medicine gasdermin metabolism pyroptosis tumor immunity tumor microenvironment |
| title | Pyroptosis, metabolism, and tumor immune microenvironment |
| title_full | Pyroptosis, metabolism, and tumor immune microenvironment |
| title_fullStr | Pyroptosis, metabolism, and tumor immune microenvironment |
| title_full_unstemmed | Pyroptosis, metabolism, and tumor immune microenvironment |
| title_short | Pyroptosis, metabolism, and tumor immune microenvironment |
| title_sort | pyroptosis metabolism and tumor immune microenvironment |
| topic | gasdermin metabolism pyroptosis tumor immunity tumor microenvironment |
| url | https://doi.org/10.1002/ctm2.492 |
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